SynthesisBMC cancer2025
Early-life exposures and risk of hematological malignancies in adulthood: a cohort study, meta-analysis and Mendelian randomization analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the global increase in annual incidence of hematological malignancies, the associations between early-life exposures and adult hematological malignancies were not well understood.
methodsBy conducting a prospective cohort study in the UK biobank, hazard ratios (HR) and 95% confidence intervals (CI) for hematological malignancies based on early-life exposures were estimated with Cox regression models. We further conducted a meta-analysis combining our study with previous cohort studies, and a two-sample Mendelian randomization (MR) analysis to evaluate the potential causal association.
resultsSmoking initiation < 14 years old, a larger body size and taller in height at age 10, were associated with an increased risk of hematological malignancies in adulthood, with corresponding HRs 1.17 (95% CI = 1.03; 1.32), 1.16 (95%CI = 1.06; 1.27) and 1.24 (95%CI = 1.14; 1.36), respectively. The associations were mediated by adulthood BMI and height, but not smoking status. Meta-analysis found no significant association for maternal smoking around birth, multiple births and breastfed as a baby. In addition, the MR analysis suggested a potential causal effect of height at age 10 and age at smoking initiation on leukemia (p < 0.05).
conclusionsTaller height at age 10 and younger age at smoking initiation were associated with an increased risk of hematological malignancies in adulthood, especially for leukemia. These findings emphasize the importance of comprehensive tobacco control among adolescents and inclusion of these factors in the assessment for hematological malignancies risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.