Observational studyBMC anesthesiology2025
Mechanical power normalized to dynamic lung compliance as a predictor of weaning and prognosis in mechanically ventilated patients: a retrospective cohort study.
Observational study in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Ventilation Intensity and Prognosis in Pediatric Oncology: Mechanical Power, Compliance, and Mortality Risk.Pediatric pulmonology · 2026Observational
- Validation of the Formulas for Mechanical Power in Children and Proposal of the Concept of "Effective Mechanical Power".Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundPredicting weaning outcomes in mechanically ventilated patients remains challenging. While mechanical power (MP) reflects ventilatory load, its accuracy is limited by variability in lung compliance. This study evaluated the predictive value of MP normalized to dynamic lung compliance (Cdyn-MP) for weaning outcomes and prognosis.
methodsA retrospective observational study was conducted in two ICUs in Jiangsu, China. Patients receiving invasive ventilation ≥ 24 h and undergoing a first spontaneous breathing trial (SBT) via T-tube were included. Patients with accidental extubation, neuromuscular disorders, or without available medical records were excluded. Respiratory mechanics data prior to SBT were retrospectively extracted from medical records. Associations and predictive performance were analyzed using restricted cubic spline, Spearman correlation, and time-dependent receiver operating characteristic (ROC) curves.
resultsAmong enrolled patients, 67.7% were successfully weaned, while 32.3% failed. A 100-unit increase in Cdyn-MP was associated with a 32% increased risk of weaning failure (p < 0.001). Cdyn-MP positively correlated with adverse outcomes. Time-dependent ROC curves yielded AUC values of 0.913, 0.771, 0.733, and 0.702 for predicting weaning failure within ≤ 1, ≤3, ≤ 7, and > 7 days after initial SBT.
conclusionCdyn-MP was significantly associated with weaning outcomes and prognosis in mechanically ventilated patients. Its routine evaluation may enhance prediction accuracy and support traditional weaning assessments.
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