ReviewTopics in current chemistry (Cham)2025
Palladium-Catalyzed Tsuji-Trost-Type Reactions in Bioorthogonal Chemistry: From Test Tubes to Living Systems.
Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Revisiting C4N4 Fluorophore: Theoretical Elucidation of the Origin of Fluorescent Properties of 2,5-Diaminopyrimidines and Strategic Applications to Pd Detection.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The potential to conduct palladium-catalyzed Tsuji-Trost reactions in biological systems opens unprecedented opportunities to probe and manipulate cellular processes. However, implementing such transformations remains challenging due to the stringent requirements imposed by biocompatibility. To date, Tsuji-Trost allylation has not yet been successfully demonstrated in living cells, and in vivo applications remain unrealized, primarily due to the presumed incompatibility between traditional organic chemistry and the complex aqueous environments of biological systems. Nevertheless, significant progress has been made in this area over the past two decades. The successful execution of a Tsuji-Trost reaction in aqueous media requires careful consideration of several key factors, including the choice of catalyst, ligand, leaving group, and nucleophile, as well as the influence of water on reactivity and selectivity. In this review, we highlight the latest advancements in biocompatible palladium-catalyzed Tsuji-Trost-type reactions, with a particular focus on deprotection and allylation reactions conducted in aqueous environments and in living systems. Further development of in vivo Tsuji-Trost allylation is expected in the near future.
Indexed as
Identifiers
41062887What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.