Evidence map›Paper›PMID 41062877›Full record

ArticleStem cell reviews and reports2026

Comparative Effects of Repeated Intravenous Infusions of Progenitor Cells in a Rat Model of Chronic Ischemic Cardiomyopathy.

Xian-Liang Tang, Marcin Wysoczynski, Yan Li, Shengnan Zheng, Anna M Gumpert, Wen-Jian Wu, Qinghui Ou, Luo Li, Halina Ruble, Heather Stowers and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xian-Liang TangDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Marcin WysoczynskiDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Yan LiDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Shengnan ZhengDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Anna M GumpertDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Wen-Jian WuDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Qinghui OuDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Luo LiDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Halina RubleDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Heather StowersDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA.
Roberto BolliDivision of Cardiovascular Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY, 40292, USA. rbolli@louisville.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleAlthough direct cardiac delivery of bone marrow-derived mesenchymal stromal cells (MSCs), c-kit-positive (c-kit

objectiveTo directly compare the effects of 3 repeated intravenous infusions of syngeneic MSCs, CPCs, and CMCs in a well-established rat model of chronic ICM. METHODS AND

resultsRats with a 30-day-old myocardial infarction (MI) received 3 repeated intravenous infusions, 35 days apart, of vehicle (Dulbecco's phosphate-buffered saline [DPBS]), MSCs, CMCs, or CPCs, at a dose of 12 × 10

conclusionsThree repeated intravenous infusions of allogeneic MSCs, CPCs, or CMCs improved echocardiographic measures of LV function and reduced myocardial fibrosis in rats with chronic MI. However, only MSCs and CPCs improved hemodynamic indices of LV function and reduced hypertrophy and inflammation in the viable, noninfarcted myocardium. These data confirm the effectiveness of intravenous cell delivery in alleviating ICM and suggest therapeutic superiority of MSCs and CPCs over CMCs.

Indexed as

CardiomyopathiesMesenchymal Stem Cell TransplantationMyocardial IschemiaStem CellsAnimalsChronic DiseaseDisease Models, AnimalInfusions, IntravenousMaleMesenchymal Stem CellsMyocardial InfarctionRatsVentricular Function, LeftFibrosisInflammationIntravenousIschemic cardiomyopathyIschemic heart failureMyocardial infarctionStem cells

Identifiers

PMID41062877

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.