ArticleAnalytical and bioanalytical chemistry2025
Screening of selective serotonin reuptake inhibitors from Cyperus rotundus using immobilized neurotransmitter transporter affinity chromatography for antidepressant discovery.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite advances in targeting neurotransmitter transporters, developing selective serotonin reuptake inhibitors (SSRIs) remains crucial for treating psychiatric disorders. Here, we developed an innovative affinity chromatography platform to discover novel SSRIs from Cyperus rotundus (CR), utilizing immobilized serotonin transporter (SERT) as the capture probe. Our approach employed genetically encoded unnatural amino acids (UAAs) and a "thiol-ene" click reaction to create a stable, functional SERT stationary phase. This immobilized SERT chromatography demonstrated superior specificity and longevity, enabling reliable ligand-receptor interaction analysis and inhibitor screening. Validation studies confirmed the platform's accuracy, with ligand affinity rankings matching conventional radioimmunoassay results. Through this method, we identified α-cyperone as a potent SERT inhibitor from CR, exhibiting high binding affinity (6.97 × 10
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