Evidence map›Paper›PMID 41062846›Full record

ArticleAnnals of biomedical engineering2025

Chitosan Nanofibrous Dressing Increased Angiogenesis and Anti-inflammatory Response in an Acute Wound Model in Rats: A Comparative Study.

Yury Salkovskiy, Mahboubeh Ghanbari, Carlos P Jara, Sara Cartwright, Pinaki Mondal, Colman Freel, Sayed Ahmadreza Razian, Jason MacTaggart, Mark A Carlson

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yury SalkovskiyDepartment of Biomechanics, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE, 68182, USA. ysalkovskiy@unomaha.edu.ORCID http://orcid.org/0000-0001-8364-4167
Mahboubeh GhanbariDepartment of Biomechanics, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE, 68182, USA.ORCID http://orcid.org/0009-0006-9038-7596
Carlos P JaraDepartment of Surgery, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.ORCID http://orcid.org/0000-0001-5444-721X
Sara CartwrightDepartment of Surgery, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.ORCID http://orcid.org/0009-0001-9722-4734
Pinaki MondalDepartment of Surgery, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.ORCID http://orcid.org/0000-0002-1465-1475
Colman FreelCollege of Medicine, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.ORCID http://orcid.org/0000-0003-0820-1221
Sayed Ahmadreza RazianDepartment of Biomechanics, University of Nebraska at Omaha, 6160 University Drive South, Omaha, NE, 68182, USA.ORCID http://orcid.org/0000-0002-6134-5550
Jason MacTaggartDepartment of Surgery, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.ORCID http://orcid.org/0000-0003-1204-699X
Mark A CarlsonDepartment of Surgery, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198, USA.ORCID http://orcid.org/0000-0002-8113-9199

Funding

Visual control of locomotion in people with Parkinsons diseaseP20GM109090 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI STERGIOU, NIKOLAOS · 2014 to 2023
$20.5M
Tissue Analysis Core (TAC)P20GM152301 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI Alexey Kamenskiy · 2024 to 2026
$8.8M
Nebraska Research Initiative 51381NIGMS NIH HHS P20 GM109090NIGMS NIH HHS P20GM109090NIGMS NIH HHS P20 GM152301NIGMS NIH HHS P20GM152301
6 · The paper itself

Abstract

purposeChitosan-based materials are promising for wound healing because of their antibacterial efficacy, biocompatibility, and biodegradability, though their healing mechanisms remain unclear. This study explores the cellular and molecular mechanisms of wound healing with chitosan nanofibrous dressings.

methodsThirty-nine Sprague Dawley rats were divided into three groups based on the type of dressings administered: (1) chitosan nanofibrous dressing + transparent film, (2) commercial scaffold + transparent film, and (3) transparent film alone (control). Full-thickness wounds (2 cm × 2 cm) were created on the dorsum, splinted, and covered with dressings. Evaluations at 7, 14, and 21 days included histological analysis, and measurements of TNF-α and iNOS levels in the wounds.

resultsOn day 21, epithelialization was significantly higher in the chitosan group than in the scaffold group (87.5% vs. 42.0%, p = 0.03). TNF-α levels were lower in both treatment groups compared to the controls. In the chitosan group, the CD68+/CD163+ ratio was lower than in the scaffold group (0.28 vs. 0.62, p = 0.037), and blood vessel formation was greater than in the controls.

conclusionThese results suggest that chitosan nanofibrous dressings enhance acute wound healing in rats by promoting re-epithelialization, neovasculogenesis, and maintaining low TNF-α levels in the later phases of healing.

Indexed as

BandagesChitosanNanofibersNeovascularization, PhysiologicWound HealingAngiogenesisAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyTumor Necrosis Factor-alphaChitosanTumor Necrosis Factor-alphaAcute woundAngiogenesisChitosanNanofibersPriMatrixRats

Identifiers

PMID41062846
PMCPMC12686052

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.