ReviewCommunications biology2025
Molecular mediators of cold adaptation in mammalian cells.
Review in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Frozen and Scorched: Genomic Signatures of Adaptive Divergence and Hibernation in the Living FossilEcology and evolution · 2026Article
- Accidental hypothermia.Nature reviews. Disease primers · 2026Review
- Genetic inactivation of TRPM4 does not alter the temperature-dependent movement of mouse microglia.The journal of physiological sciences : JPS · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Cold exposure increases aortic dissection risk through extracellular cold inducible RNA binding protein and toll like receptor 4 signaling.Scientific reports · 2026Article
- Mechanisms of Protection Against Oxidative Stress During Hibernation.International journal of molecular sciences · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothermia is defined as a drop in temperature below the homeostatic range of cells and tissues. This elicits a response in mammalian cells geared towards cellular and metabolic adaptation. Hibernating mammals provide natural models of cold tolerance and adaptation. Mammalian cells across species share signaling mechanisms for adaptation to hypothermic stimuli. Key molecular mediators of hypothermic signaling, including: (i) cold-sensing ion channels such as TRPM8 and TRPA1, which link temperature changes to calcium signaling and thermoregulatory responses; (ii) β-adrenergic signaling and uncoupling protein 1 (UCP1)-mediated non-shivering thermogenesis in brown adipose tissue; (iii) cold-induced epigenetic modifications such as histone acetylation, DNA methylation, and enhancer activation that imprint transcriptional memory of cold exposure; and (iv) RNA-binding proteins CIRBP and RBM3, which are rapidly induced during mild-to-moderate hypothermia and confer neuroprotection, enhance differentiation, and modulate metabolism. Together, these findings outline a molecular framework by which mammalian cells sense, respond, and adapt to cold, with implications for neuroprotection, metabolic health, and therapeutic hypothermia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.