ArticleNature2025
A parabrachial hub for need-state control of enduring pain.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
16 citing papers in PubMed.
- Natural and engineered safe reinforcement learning.Communications psychology · 2026Review
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- Peripheral NabioRxiv : the preprint server for biology · 2026Article
- Article
- A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv : the preprint server for biology · 2026Article
- Article
- Hypothalamic prolactin receptorNature communications · 2026Article
- Enhanced substance P-NK1R signaling in the parabrachial-parasubthalamic pathway promotes hyperalgesia and affective aversion in neuropathic pain.Acta pharmacologica Sinica · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Parabrachial bombesin receptor subtype 3 neurons facilitate heat hypersensitivity in persistent pain.bioRxiv : the preprint server for biology · 2026Article
- Article
- The gatekeeper of ongoing pain: an endogenous analgesic circuit that prioritizes survival.Nature reviews. Neuroscience · 2026Article
- Amygdalar calcitonin gene-related peptide driven effects of cold sensitivity induced by peripheral neuropathy in mice.The journal of pain · 2026Article
- Chloride Homeostasis Failure in Human Disease: KCC2/NKCC1 Microdomain Dysfunction as a Driver of Cortical Network Collapse.International journal of molecular sciences · 2026Review
- A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice.Nature communications · 2026Article
- Recent progress in chronic pain-related negative emotions and cognitive dysfunction: insights into the mechanisms underlying neural circuitry.Frontiers in cellular neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Nitsan Goldstein *Department of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Amadeus Maes *Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Heather N AllenDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), University of Florida College of Medicine, Gainesville, FL, USA.
Tyler S NelsonDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), University of Florida College of Medicine, Gainesville, FL, USA.ORCID 0000-0002-6675-4820
Kayla A KrugerDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Morgan KindelDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Albert T M YeungDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Nicholas K SmithDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3724-4522
Jamie R E CartyDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Lavinia BocciaDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Niklas BlankDepartment of Pathology, Stanford University, Stanford, CA, USA.
Emily LoDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Rachael E VillariDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Ella ChoDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Erin L MarbleDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Michelle AwhDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0002-3030-1755
Yasmina DumiatyDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.ORCID 0000-0003-1784-9361
Melissa J CheeDepartment of Neuroscience, Carleton University, Ottawa, Ontario, Canada.
Rajesh KhannaDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), University of Florida College of Medicine, Gainesville, FL, USA.
Christoph A ThaissDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8226-7718
Bradley K TaylorDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. bkt@pitt.edu.ORCID 0000-0002-5080-6120
Ann KennedyDepartment of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA. akennedy@scripps.edu.ORCID 0000-0002-3782-0518
J Nicholas BetleyDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA. jnbetley@sas.upenn.edu.ORCID 0000-0002-4014-9147
Funding
Ventromedial Hypothalamic Regulation of Metabolic Changes Induced by ExerciseP01DK119130 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GAUTRON, LAURENT · 2019 to 2023
$10.0MDefining the functional organization of cerebellar output circuits that control feeding behaviorR01DK124801 · NIDDK · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI BETLEY, JOHN NICHOLAS, CHEN, ALBERT · 2021 to 2024
$2.7MSentrin proteases, CRMP2 deSUMOylation, and Chronic PainR01NS120663 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2020 to 2021
$2.6MMemory in the enteric nervous systemDP1DK140021 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Christoph Alexander Thaiss · 2024 to 2026
$2.3MValidation of Neuropilin-1 Receptor Signaling in Nociceptive ProcessingRF1NS131165 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2023 to 2023
$2.0MIntestinal regulation of exercise performanceR01NS134976 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI John Nicholas Betley, Christoph Alexander Thaiss · 2024 to 2026
$1.6MRegulation of satiation centers in health and obesityR01DK133399 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETLEY, JOHN NICHOLAS · 2022 to 2025
$1.4MAntagonists of CRMP2 Phosphorylation for Chemotherapy-Induced Peripheral NeuropathyR61NS126026 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2022 to 2022
$1.4MModeling a Neural Circuit for Flexible Control of Innate BehaviorsR00MH117264 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KENNEDY, ANN KATHRYN · 2021 to 2023
$742kDissecting the Parabrachial Nucleus’s Role in the Development and Maintenance of Neuropathic PainK00NS124190 · NINDS · UNIVERSITY OF FLORIDA · PI Tyler Scott Nelson · 2023 to 2026
$346kNeuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic PainF32NS128392 · NINDS · UNIVERSITY OF FLORIDA · PI ALLEN, HEATHER NOEL · 2023 to 2025
$217kIdentifying the contribution of a brainstem circuit to compulsive food seekingF32DK135401 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SMITH, NICHOLAS K · 2023 to 2024
$146kNIDDK NIH HHS DP1 DK140021NIDDK NIH HHS F31 DK131870NIDDK NIH HHS F32 DK135401NIDDK NIH HHS P01 DK119130NIDDK NIH HHS R01 DK124801NIDDK NIH HHS R01 DK133399NIMH NIH HHS R00 MH117264NINDS NIH HHS F32 NS128392NINDS NIH HHS K00 NS124190NINDS NIH HHS R01 NS120663NINDS NIH HHS R01 NS134976NINDS NIH HHS R61 NS126026NINDS NIH HHS RF1 NS131165
Abstract
Long-term sustained pain following acute physical injury is a prominent feature of chronic pain conditions
Indexed as
Chronic PainPainParabrachial NucleusAdaptation, PsychologicalAnimalsCuesFemaleHungerMaleMiceNeuronsNeuropeptide YPredatory BehaviorReceptors, Neuropeptide YThirstNeuropeptide Yneuropeptide Y-Y1 receptorReceptors, Neuropeptide Y
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.