Evidence map›Paper›PMID 41062697›Full record

ArticleNature2025

Sex and smoking bias in the selection of somatic mutations in human bladder.

Ferriol Calvet, Raquel Blanco Martinez-Illescas, Ferran Muiños, Maria Tretiakova, Elena S Latorre-Esteves, Jeanne Fredrickson, Maria Andrianova, Stefano Pellegrini, Axel Rosendahl Huber, Joan Enric Ramis-Zaldivar and 7 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Effect of co-occurring mutations inFrontiers in immunology · 2026
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ferriol Calvet *Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0003-1841-9881
Raquel Blanco Martinez-Illescas *Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Ferran MuiñosInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-4651-4168
Maria TretiakovaDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-0819-9638
Elena S Latorre-EstevesDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Jeanne FredricksonDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Maria AndrianovaInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Stefano PellegriniInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Axel Rosendahl HuberInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Joan Enric Ramis-ZaldivarInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Shuyi Charlotte AnDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Elana ThiemeDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6012-1117
Brendan F KohrnDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9948-2131
Miguel L GrauInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Abel Gonzalez-PerezInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-8582-4660
Nuria Lopez-BigasInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. nuria.lopez@irbbarcelona.org.ORCID 0000-0003-4925-8988
Rosa Ana RisquesDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. rrisques@uw.edu.ORCID 0000-0002-0291-1858

Funding

Understanding the role of TP53 mutation in genetic susceptibility to ovarian cancerR01CA259384 · NCI · UNIVERSITY OF WASHINGTON · PI RISQUES, ROSA ANA · 2021 to 2025
$2.8M
PROMINENT - IRBOT2CA278668 · NCI · FUNDACIO INSTITUT DE RECERCA BIOMEDICA · PI LOPEZ-BIGAS, NURIA · 2022 to 2024
$1.0M
NCI NIH HHS OT2 CA278668NCI NIH HHS R01 CA259384
6 · The paper itself

Abstract

Men are at higher risk of several cancer types than women

Indexed as

MutationSelection, GeneticSex CharacteristicsSmokingUrinary BladderUrinary Bladder NeoplasmsAdultAgedAge FactorsClone CellsDNA-Binding ProteinsFemaleHumansMaleMiddle AgedNuclear ProteinsARID1A protein, humanDNA-Binding ProteinsNuclear ProteinsTelomeraseTERT protein, humanTranscription Factors

Identifiers

PMID41062697
PMCPMC12611770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.