ArticleNature2025
Somatic mutation and selection at population scale.
Abstract readTwin Study
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Cancer treatment alters the selection of pre-existing somatic mutations in normal esophagus.Nature genetics · 2026Article
- AlphaGenome Atlas:medRxiv : the preprint server for health sciences · 2026Article
- G12 mutations rewire allosteric communication at the Ras-RalGDS interface.Biophysical journal · 2026Article
- Article
- A guide to understanding tumour evolution through the lens of population genetics.Nature reviews. Cancer · 2026Review
- The Evolution of Polyclonal Competition in Aging Hematopoiesis.Cancer discovery · 2026Article
- Uncovering the hidden mutational landscape of the oral epithelium.Evidence-based dentistry · 2026Observational
- High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage.NPJ precision oncology · 2026Article
- Determinants of mutation susceptibility along the genome are largely invariant across human tissues.Genome biology · 2026Article
- Routes to colorectal cancer in Lynch syndrome: a decade of molecular and clinical insights converging on Schrödinger's cat.Familial cancer · 2026Review
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Understanding the somatic evolution of metabolic traits.Nature metabolism · 2026Article
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Article
- Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing.bioRxiv : the preprint server for biology · 2026Article
- Context-dependent selection sculpts mutational landscapes in the normal lung.Research square · 2026Article
- Assessing the effect of immune surveillance on clonal expansions in the blood.Nature genetics · 2026Article
- High-fidelity rare structural variant detection with HiFiRE3 reduced representation via restriction enzyme ends.bioRxiv : the preprint server for biology · 2026Article
- Effects of ethanol and acetaldehyde on multi-organ genomic mutation landscapes.Cell biology and toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors.
Andrew R J Lawson *Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-3592-1005
Federico Abascal *Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-6201-1587
Pantelis A Nicola *Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Stefanie V LensingCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Amy L RobertsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-5704-9249
Georgios KalantzisHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-0729-1125
Adrian Baez-OrtegaCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Natalia BrzozowskaCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Julia S El-Sayed MoustafaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0001-6963-6654
Dovile VaitkuteDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Belma JakupovicDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Ayrun NessaDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Samuel WadgeDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Marc F ÖsterdahlDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Anna L PatersonDepartment of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Doris M RasslDepartment of Pathology, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Raul E AlcantaraCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Laura O'NeillCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Sara WidaaSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.
Siobhan Austin-GuestSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.
Matthew D C NevilleCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-5816-7936
Moritz J PrzybillaCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-5645-9492
Wei ChengSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.
Maria MorraSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.
Lucy SykesSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-5928-6099
Matthew MayhoSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.
Nicole Müller-SienerthSequencing Operations, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-7527-5127
Nicholas WilliamsCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-3989-9167
Diana AlexanderCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-7785-3170
Luke M R HarveyCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Thomas ClarkeCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Alex ByrneCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.
Jamie R BlundellEarly Cancer Institute, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID 0000-0001-9747-7363
Matthew D YoungQuotient Therapeutics Limited, Saffron Walden, UK.
Krishnaa T A MahbubaniDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1327-2334
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge, Cambridge, UK.ORCID 0000-0002-0633-3696
Hilary C MartinHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-4454-9084
Michael R StrattonCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-6035-153X
Peter J CampbellCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-3921-0510
Raheleh RahbariCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-1839-7785
Kerrin S SmallDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0003-4566-0005
Iñigo MartincorenaCancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK. im3@sanger.ac.uk.ORCID 0000-0003-1122-4416
Funding
Wellcome Trust
Abstract
As we age, many tissues become colonized by microscopic clones carrying somatic driver mutations
Indexed as
High-Throughput Nucleotide SequencingMutationSelection, GeneticAgingClone CellsCohort StudiesEpitheliumFemaleHumansMaleMouth MucosaMutation RateNeoplasmsRisk Factors
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.