ArticleScientific reports2025
Secoisopimaranes from Salvia elegans Vahl leaves as antibacterial agents against Staphylococcus aureus.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Mapping antimicrobials in plant lineages.Frontiers in plant science · 2026Article
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7 authors.
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Abstract
The genus Salvia contains around 1000 species and is primarily known to produce caffeic acid polymers and diterpenes. Of the bi- and tricyclic classes of diterpenes found in Salvia, isopimaranes are the least represented. The bio-guided metabolomic analysis of the leaves of Salvia elegans Vahl revealed the occurrences of three secoisopimaranes (1-3), of which the known 3,4-secoisopimara-7,15-dien-3-oic acid was the most abundant and showed potent antimicrobial activity against Staphylococcus aureus with a MIC = 15.6 µg/mL (51.6 µM). All three diterpenes were detected in domesticated and wild specimens of the closely related species Salvia cinnabarina M.Martens & Galeotti, but not in other species reportedly to be closely related to S. elegans. Diterpenoids from Salvia are an interesting group of biologically active molecules and their distribution within the genus justifies further study.
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