ArticleScientific reports2025
Antimicrobial mechanical and molecular docking analysis of dental composite resin incorporating green synthesized titanium dioxide nanoparticles from Vitis vinifera extract.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
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Who cites it
7 citing papers in PubMed.
- Clinical Performance of Bulk-Fill Versus Incremental Composite Placement Approaches in Vital Posterior Teeth: A 24 Months Randomized Controlled Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Trial
- Effects of dry mouth lozenges on the surface morphology and color stability of restorative materials.Odontology · 2026Article
- Effect of polymerization mode and LED light-curing units on the shear bond strength of an alkasite restorative material to dentin.Odontology · 2026Article
- Influence of commercial mouth rinses with different formulations on enamel properties during at-home bleaching.Odontology · 2026Article
- Article
- Green-Synthesized titanium dioxide Nanoparticle-Modified glass ionomer cement: in vitro and in Silico assessment of Mechanical, Physical, and safety properties performance.Scientific reports · 2026Article
- Evaluating the remineralisation potential and clinical evidence of emerging biocompatible materials in restorative dentistry: a systematic review.Biomaterial investigations in dentistry · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental composites are widely used restorative materials but secondary caries to the restored tooth, polymerization shrinkage, and mechanical failure, limiting their longevity. Incorporating nanoparticles synthesized via eco-friendly methods offers a promising strategy to enhance composite performance. This study introduces a novel, eco-friendly strategy to enhance dental composite resins by incorporating TiO₂-NPs synthesized using Vitis vinifera extract. This study uniquely employs Vitis vinifera, rich in flavonoids and phenolics, as a reducing and capping agent, and for the first time integrates molecular docking analysis to explore the mechanistic antimicrobial interaction between TiO₂-NPs and Streptococcus mutans glucosyltransferase. The research evaluates the impact of these green-synthesized nanoparticles on antimicrobial properties, mechanical performance, polymerization shrinkage, and their molecular interactions with Streptococcus mutans glucosyltransferase via molecular docking analysis. The green-synthesized TiO₂-NPs were thoroughly characterized and integrated into dental composites at 10% and 20% by weight (Groups II and III, respectively), while Group I (control) contained only fumed silica fillers. The antimicrobial activity was assessed against S. mutans, S. sanguinis, and L. acidophilus, and mechanical properties (flexural strength and microhardness) were evaluated according to ISO standards. Polymerization shrinkage was measured using a strain gauge. Additionally, molecular docking analysis was performed to investigate the interaction of TiO₂-NPs with S. mutans glucosyltransferase. The modified composites exhibited significantly improved antimicrobial activity against key oral pathogens and superior mechanical properties compared to the control. Molecular docking studies provided insights into the potential antimicrobial mechanisms of TiO₂-NPs. These findings suggest that green-synthesized TiO₂-NPs offer a promising, eco-friendly approach to improve the performance and longevity of dental restorative materials.
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