Evidence map›Paper›PMID 41062640›Full record

ArticleCommunications medicine2025

Utilizing a publicly accessible automated machine learning platform to enable diagnosis before tumor surgery.

Farideh Hosseinzadeh, George Liu, Esmond Tsai, Ahmad Mahmoudi, Angela Yang, Dayoung Kim, Maxime Fieux, Lirit Levi, Soraya Abdul-Hadi, Nithin D Adappa and 54 more

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Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors.

Farideh HosseinzadehDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1555-4711
George LiuDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Esmond TsaiDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Ahmad MahmoudiDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3397-674X
Angela YangDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Dayoung KimDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Maxime FieuxDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8317-2286
Lirit LeviDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Soraya Abdul-HadiDepartment of Otolaryngology-Head & Neck Surgery, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Nithin D AdappaDepartment of Otolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Jeremiah A AltDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, UT, USA.
Khaled A AltartoorDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Norbert BanyiDepartment of Surgery, St. Paul's Sinus Centre, University of British Columbia, Vancouver, BC, Canada.
Megana ChallaDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center, San Antonio, TX, USA.
Rakesh ChandraDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.
Michael T ChangDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Philip G ChenDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-5468-3324
Do-Yeon ChoDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Camila Rios de ChoudensDepartment of Otolaryngology-Head & Neck Surgery, University of Puerto Rico School of Medicine, San Juan, PR, USA.ORCID http://orcid.org/0000-0002-1389-0909
Naweed ChowdhuryDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.
Clariliz Munet ColonDepartment of Otolaryngology-Head & Neck Surgery, University of Puerto Rico School of Medicine, San Juan, PR, USA.
John M DelGaudioDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Anthony Del SignoreDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Icahn School of Medicine, New York, NY, USA.
Christina DorismondDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-4333-9763
Daniel DutraDepartment of Otolaryngology-Head and Neck Surgery, Central Adelaide Local Head Network and University of Adelaide, Adelaide, Australia.
Shaun EdalatiDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Icahn School of Medicine, New York, NY, USA.
Thomas S EdwardsDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6290-9506
Jose Busquets FerriolDepartment of Otolaryngology-Head & Neck Surgery, University of Puerto Rico School of Medicine, San Juan, PR, USA.
Mathew GeltzeilerDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, OR, USA.
Christos GeorgalasMedical School, University of Nicosia, 93 Agiou Nikolaou Street, Engomi, Nicosia, Cyprus.
Satish GovindarajDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Icahn School of Medicine, New York, NY, USA.
Jessica W GraysonDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
David A GudisDepartment of Otolaryngology-Head and Neck Surgery, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID http://orcid.org/0000-0002-1938-9349
Richard J HarveyMacquarie University, Medicine and Health Sciences, Sydney, Australia.ORCID http://orcid.org/0000-0002-6942-8975
Austin HeffernanDepartment of Surgery, St. Paul's Sinus Centre, University of British Columbia, Vancouver, BC, Canada.
Peter H HwangDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Alfred Marc IloretaDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Icahn School of Medicine, New York, NY, USA.
Nicolaus D KnightDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Michael A KohanskiDepartment of Otolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8399-364X
David K LernerDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Icahn School of Medicine, New York, NY, USA.
Argyro LeventiMedical School, University of Nicosia, 93 Agiou Nikolaou Street, Engomi, Nicosia, Cyprus.ORCID http://orcid.org/0009-0007-1945-0289
Lik Hang LeeDepartment of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Rory LubnerDepartment of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-9884-2799
Chengetai MahomvaDepartment of Surgery, University of South Dakota, Sioux Falls, SD, USA.
Conner MasseyDepartment of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, UT, USA.
Edward D McCoulDepartment of Otorhinolaryngology, Ochsner Health, New Orleans, LA, USA.ORCID http://orcid.org/0000-0003-1812-2105
Jayakar V NayakDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4454-0861
Ezra Pak-HarveyDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.
James N PalmerDepartment of Otolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Vivek C PandrangiDepartment of Otolaryngology-Head and Neck Surgery, Oregon Health & Science University, Portland, OR, USA.
Alkis J PsaltisDepartment of Otolaryngology-Head and Neck Surgery, Central Adelaide Local Head Network and University of Adelaide, Adelaide, Australia.
Joseph RavivEndeavor Health, Evanstown, IL, USA.
Peta SacksMacquarie University, Medicine and Health Sciences, Sydney, Australia.
Ray SacksMacquarie University, Medicine and Health Sciences, Sydney, Australia.
Madeleine SchabergDepartment of Otolaryngology-Head and Neck Surgery, Mount Sinai Icahn School of Medicine, New York, NY, USA.
Ethan SoudryDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.
Auddie SweisEndeavor Health, Evanstown, IL, USA.
Andrew ThambooDepartment of Surgery, St. Paul's Sinus Centre, University of British Columbia, Vancouver, BC, Canada.
Justin H TurnerDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Steve X WangDepartment of Otorhinolaryngology, Ochsner Health, New Orleans, LA, USA.
Sarah K WiseDepartment of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Bradford A WoodworthDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Peter-John WormaldDepartment of Otolaryngology-Head and Neck Surgery, Central Adelaide Local Head Network and University of Adelaide, Adelaide, Australia.
Zara M PatelDepartment of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA. zmpatel@stanford.edu.ORCID http://orcid.org/0000-0003-2072-982X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn benign tumors with potential for malignant transformation, sampling error during pre-operative biopsy can significantly change patient counseling and surgical planning. Sinonasal inverted papilloma (IP) is the most common benign soft tissue tumor of the sinuses, yet it can undergo malignant transformation to squamous cell carcinoma (IP-SCC), for which the planned surgery could be drastically different. Artificial intelligence (AI) could potentially help with this diagnostic challenge.

methodsCT images from 19 institutions were used to train the Google Cloud Vertex AI platform to distinguish between IP and IP-SCC. The model was evaluated on a holdout test dataset of images from patients whose data were not used for training or validation. Performance metrics of area under the curve (AUC), sensitivity, specificity, accuracy, and F1 were used to assess the model.

resultsHere we show CT image data from 958 patients and 41099 individual images that were labeled to train and validate the deep learning image classification model. The model demonstrated a 95.8 % sensitivity in correctly identifying IP-SCC cases from IP, while specificity was robust at 99.7 %. Overall, the model achieved an accuracy of 99.1%.

conclusionsA deep automated machine learning model, created from a publicly available artificial intelligence tool, using pre-operative CT imaging alone, identified malignant transformation of inverted papilloma with excellent accuracy.

Identifiers

PMID41062640
PMCPMC12508036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.