Evidence map›Paper›PMID 41062634›Full record

ArticleScientific reports2025

Low-dose nivolumab plus induction chemotherapy for locally advanced or unresectable head and neck cancer is associated with high response rates and conversion to definitive therapy.

Josh Thomas Georgy, Soumya Susan Regi, Rosh Varghese Georgy, Balu Krishna Sasidharan, Anjana Joel, Deepa Susan Joy Philip, Ajoy Oommen John, Divya Bala Thumaty, Praveen Kumar Marimuthu, Prashant Jambunathan and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Josh Thomas GeorgyDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Soumya Susan RegiDepartment of Radiodiagnosis, Christian Medical College Vellore, Vellore, India.
Rosh Varghese GeorgyDepartment of Radiodiagnosis, Christian Medical College Vellore, Vellore, India.
Balu Krishna SasidharanDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore, India.
Anjana JoelDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Deepa Susan Joy PhilipDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Ajoy Oommen JohnDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Divya Bala ThumatyDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Praveen Kumar MarimuthuDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Prashant JambunathanDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Kovilapu HarikrishnaDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India.
Zachariah ThomasDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
N Jansi RaniDepartment of Biostatistics, Christian Medical College Vellore, Vellore, India.
Amit Jiwan TirkeyDepartment of Head and Neck Surgery, Christian Medical College Vellore, Vellore, India.
Meera ThomasDepartment of General Pathology, Christian Medical College Vellore, Vellore, India.
Rajesh IsiahDepartment of Radiation Oncology, Christian Medical College Vellore, Vellore, India.
Ashish SinghDepartment of Medical Oncology, Christian Medical College Vellore, Vellore, Tamil Nadu, 632517, India. ashishsingh@cmcvellore.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Locally advanced head and neck squamous cell carcinoma (LAHNSCC) unresectable at presentation has a dismal survival when radical surgery or definitive chemoradiation is not possible. This ambispective cohort study evaluated the addition of low-dose nivolumab to induction chemotherapy (IC) for locally advanced, unresectable or borderline resectable HNSCC. 111 patients with stage III-IVB disease received IC with low-dose nivolumab (< 240 mg or < 3 mg kg

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsHead and Neck NeoplasmsInduction ChemotherapyNivolumabSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingProgression-Free SurvivalTreatment OutcomeNivolumabConversionCost-effectivenessInduction chemoimmunotherapyLow-dose nivolumabUnresectable HNSCC

Identifiers

PMID41062634
PMCPMC12508025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.