Evidence map›Paper›PMID 41062622›Full record

ArticleScientific reports2025

TXNIP mediates ferroptosis in a bronchopulmonary dysplasia mouse model by regulating the SLC7A11/GPX4 pathway.

Dongzhui Chen, Feifei Yin, Pin Yang, Wanrong Xia, Yi Huang, Yue Feng, Li Yang, Shuqiang Lin, Qiuyue Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dongzhui ChenThe First School of Clinical Medicine, Hainan Medical University, Haikou, 570102, Hainan, China.
Feifei YinHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan, China.
Pin YangHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan, China.
Wanrong XiaHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan, China.
Yi HuangHainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Key Laboratory of Tropical Translational Medicine of Ministry of Education, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan, China.
Yue FengDepartment of Pediatrics, First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China.
Li YangThe First School of Clinical Medicine, Hainan Medical University, Haikou, 570102, Hainan, China.
Shuqiang LinThe First School of Clinical Medicine, Hainan Medical University, Haikou, 570102, Hainan, China.
Qiuyue ZhangDepartment of Pediatrics, First Affiliated Hospital of Hainan Medical University, Haikou, 570102, Hainan, China. hy0203157@muhn.edu.cn.

Funding

Graduate Innovation Research Project of Hainan Province, China Qhys2023-464the National Natural Science Foundation of China No. 82060289
6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common respiratory diseases in preterm infants. Studies have shown that ferroptosis is involved in the pathogenesis of BPD, and thioredoxin-interacting protein (TXNIP)-mediated oxidative stress also plays a role in its development. The solute carrier family 7 member 11 (SLC7A11)/glutathione peroxidase 4 (GPX4) signaling pathway is one of the key pathways regulating ferroptosis. This study aimed to investigate the mechanism by which TXNIP regulates SLC7A11/GPX4 pathway-mediated ferroptosis in BPD. Mice were randomly divided into ten treatment groups: Air, Hyperoxia, Hyperoxia + RSL3, Hyperoxia + Ferrostatin-1, Hyperoxia + Ad-shNC, Hyperoxia + Ad-shTXNIP, Hyperoxia + Ad-vector, Hyperoxia + Ad-TXNIP, Hyperoxia + Ad-shSLC7A11, and Hyperoxia + Ad-shTXNIP + Ad-shSLC7A11. Lung tissues were collected for hematoxylin and eosin (H&E) staining to observe pathological changes, and transmission electron microscopy (TEM) was used to examine mitochondrial morphology. Real-time quantitative polymerase chain reaction (qPCR) was performed to measure the mRNA expression of TXNIP, SLC7A11, and GPX4. Western blotting was used to analyze the protein levels of TXNIP, SLC7A11, and GPX4. GPX4 activity was determined using an enzyme-linked immunosorbent assay (ELISA). Additionally, glutathione (GSH), malondialdehyde (MDA), and ferrous iron (Fe

Indexed as

Amino Acid Transport System y+Bronchopulmonary DysplasiaCarrier ProteinsFerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseThioredoxinsAnimalsDisease Models, AnimalHumansHyperoxiaLungMiceMice, Inbred C57BLOxidative StressSignal TransductionAmino Acid Transport System y+Carrier Proteinsglutathione peroxidase 4, mousePhospholipid Hydroperoxide Glutathione PeroxidaseSlc7a11 protein, mouseThioredoxinsTxnip protein, mouseAdenovirus serotype 5Bronchopulmonary dysplasiaFerroptosisOxidative stressThioredoxin-interacting protein

Identifiers

PMID41062622
PMCPMC12508065

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.