ArticleNPJ Parkinson's disease2025
The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Convergent Astrocytic Failure in Parkinson's Disease: A System-Level Model of Pathogenesis and Treatment.Molecular neurobiology · 2026Review
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Review
- Alterations in the DTI-ALPS index and choroid plexus volume are associated with symptom severity in children with tic disorders.BMC neurology · 2026Article
- Glymphatic surrogate, choroid plexus remodeling, and exploratory brain network analysis in the post-acute phase of anti-NMDAR encephalitis: multimodal MRI evidence for cognitive associations and differential white matter mediation.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Growing evidence suggests that the glymphatic system, driven by aquaporin-4 (AQP4) water channels, plays a key role in Parkinson's disease (PD). We examined the impact of specific AQP4 variants on glymphatic function using diffusion tensor imaging along the perivascular space (DTI-ALPS), and explored potential mechanisms underlying motor symptom severity and progression in PD. PD participants exhibited lower DTI-ALPS indices compared to controls. Reduced DTI-ALPS at baseline was linked to more severe motor symptoms and faster longitudinal motor decline, as assessed by the Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Part III (MDS-UPDRS III). One specific AQP4 variant was associated with decreased DTI-ALPS and increased MDS-UPDRS III scores, with DTI-ALPS mediating this relationship at baseline and follow-up. Some variants exhibited indirect protective effects on motor symptoms via enhanced glymphatic function. These findings indicate that AQP4 polymorphisms contribute to glymphatic dysfunction and motor progression in PD, supporting strategies for disease modification.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.