ReviewNPJ vaccines2025
The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy.
Review in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Plasmepsins as Antimalarial Drug Targets-Then, Now, and the Future.Medicinal research reviews · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Genetically attenuated parasites (GAPs) that arrest during liver stage development have shown significant potential as malaria vaccines. Compared to Plasmodium falciparum GAPs that arrest after 24-48 h (early-arresters), parasites arresting after 6-7 days (late-arresters) have shown superior efficacy, highlighting the importance of liver stage immunity in promoting sterile protection. Here, we describe GAPs tested in humans and the pre-clinical research that led to their creation. We discuss safety and efficacy of existing GAPs with particular focus on their large-scale implementation as malaria vaccines.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.