ArticleNature communications2025
A scope of prebiotic neat reaction conditions and the mechanism of urea-assisted phosphorylations of alcohols.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Concurrent Phosphite Oxidation and Adenosine Phosphorylation Under Prebiotic Evaporative Conditions.Journal of molecular evolution · 2026Article
- Chemical Routes to Primitive Membranes: Prebiotic Lipid Formation at the Origin of Life.Life (Basel, Switzerland) · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two theories of the origin of life on Earth, one located in the Hadean seafloor, the other on the surface of subaerial landmasses and basins, need reconcilement. Natural energy flows moulded seafloors to locally sustain chemical reaction networks reminiscent of metabolism. Subaerial hot milieus gathered organic phosphates to provide robust compartments from phospholipids and heredity from nucleic acid replication and translation. Here, we report on the efficiency and product distribution of the phosphorylation of twelve model alcohols reacting separately, and in selected combinations, all under the same chemically activated conditions, mostly as neat hot solid-liquid mixtures. We afford proof for the dominant reaction mechanism and indicate how prebiotic seafloor and subaerial systems could profit from one another through atmospheric and tidal exchange of organic material.
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