Evidence map›Paper›PMID 41062467›Full record

ArticleNature communications2025

Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1.

Behnaz Davoudinasab, Aleksey Raskovalov, Woojin Lee, Donggyun Kim, Heesoo Kim, Jordy Homing Lam, Gye Won Han, Vsevolod Katritch, Vadim Cherezov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Behnaz DavoudinasabDepartment of Chemistry, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0008-1425-3902
Aleksey Raskovalov *Department of Chemistry, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1207-5312
Woojin Lee *Bridge Institute, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8531-0301
Donggyun KimDepartment of Chemistry, University of Southern California, Los Angeles, CA, USA.
Heesoo KimDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Jordy Homing LamBridge Institute, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5496-6228
Gye Won HanBridge Institute, University of Southern California, Los Angeles, CA, USA.
Vsevolod KatritchDepartment of Chemistry, University of Southern California, Los Angeles, CA, USA. katritch@usc.edu.ORCID http://orcid.org/0000-0003-3883-4505
Vadim CherezovDepartment of Chemistry, University of Southern California, Los Angeles, CA, USA. cherezov@usc.edu.ORCID http://orcid.org/0000-0002-5265-3914

Funding

The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8M
Structural Biology Of G Protein-Coupled ReceptorsR35GM127086 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Vadim Cherezov · 2018 to 2026
$3.6M
Computational approaches to discover ligands with new chemotypes and functional propertiesR35GM153437 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VSEVOLOD KATRITCH · 2024 to 2026
$899k
NIGMS NIH HHS R35 GM127086NIGMS NIH HHS R35 GM153437NIGMS NIH HHS U24 GM129541U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM127086U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM153437
6 · The paper itself

Abstract

The prostaglandin D2 receptor 1 (DP1), a member of the prostanoid G protein-coupled receptor (GPCR) family, plays critical roles in allergic responses, sleep regulation, immune modulation, and vasodilation. Here, we present five high-resolution cryo-electron microscopy (cryo-EM) structures of the human DP1 receptor, including an apo structure, two inactive state structures bound to two different inverse agonists developed by ONO Pharmaceutical, and two active state structures in complex with the G

Indexed as

Receptors, ImmunologicReceptors, ProstaglandinBinding SitesCryoelectron MicroscopyHEK293 CellsHumansLigandsMolecular Dynamics SimulationMutagenesis, Site-DirectedProstaglandin D2Protein BindingLigandsProstaglandin D2prostaglandin D2 receptorprostanoid D receptor 1, humanReceptors, ImmunologicReceptors, Prostaglandin

Identifiers

PMID41062467
PMCPMC12508460

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.