Evidence map›Paper›PMID 41062454›Full record

ArticleNucleic acids research2026

PCsRNAdb: a comprehensive resource of small noncoding RNAs across cancers.

Rende Huang, Jiang Li, Qi Cao, Lixia Wang, Zhixiong Shao, Haochun Yang, Xinlei Zhang, Chuanlai Yang, Xiangya Kong, Qiuyue Gu and 6 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rende HuangDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Jiang LiClinical Big Data Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Qi CaoZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.
Lixia WangDepartment of Urology, The Second Affiliated Hospital of Soochow University, Suzhou Jiangsu 215006, China.
Zhixiong ShaoZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.
Haochun YangZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.
Xinlei ZhangBeijing Cloudna Technology Company, Limited, Beijing 100029, China.
Chuanlai YangDepartment of Urology, The Second Affiliated Hospital of Soochow University, Suzhou Jiangsu 215006, China.
Xiangya KongBeijing Cloudna Technology Company, Limited, Beijing 100029, China.
Qiuyue GuBeijing Cloudna Technology Company, Limited, Beijing 100029, China.
Jianmin WuBiomics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.
Tsan-Yu ChiuBiomics Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.
Penghu LianPeking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Kui WuZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.
Feng GaoDepartment of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Zhongxu ZhuZhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310018, China.ORCID 0000-0003-2197-5563

Funding

Chinese Academy of Medical Sciences 2023-I2M-C&T-B-021Chinese Academy of SciencesGuangdong Basic and Applied Basic Research Foundation 2024A1515012269Guangzhou Basic and Applied Basic Research Fund 2024A04J9983Hangzhou Institute of MedicineNational Key Clinical DisciplineNational Natural Science Foundation of China 32370978National Natural Science Foundation of China 82272422National Science and Technology 2025ZD0551700National Science and Technology Major Project 2023ZD0501600Shenzhen Medical Research Special Project D2401005Tianshan Talents · Leading Medical Talents in Guangdong Province Cooperative Expert Studio 2020B1111170004Tianshan Talents · Leading Medical Talents in Guangdong Province Cooperative Expert Studio KSYJ2022001
6 · The paper itself

Abstract

Small noncoding RNAs (sncRNAs) constitute a diverse class of endogenous transcripts, including miRNAs, piRNAs, tRNA-derived fragments (tDRs), rRNA-derived fragments (rRFs), and other small RNAs. They have been identified as pivotal regulatory elements in a wide array of biological processes and diseases. Among these, miRNA is the most extensively studied and confirmed as a key regulatory and diagnostic biomarker in tumorigenesis and development. However, the current understanding of sncRNAs other than miRNA remains limited, particularly in the field of oncology. To this end, we collected 190 datasets from GEO/SRA database, encompassing 11 114 samples across 19 cancer types, and built a user-friendly database, the Pan-Cancer Small Non-Coding RNA Database (PCsRNAdb, http://pcsrnadb.cloudna.cn/#/Home), which is developed to provide abundant resources of sncRNAs specifically designed to investigate the association between sncRNAs and cancers. PCsRNAdb comprehensively provides basic information such as the sequence, length, abundance, and target genes of sncRNAs, and further offers four advanced functionalities, including differential expression analysis, survival analysis, expression profiling analysis, and network regulatory analysis. We anticipate that such platform offers invaluable resources and effective analytical tools for researchers in related fields and is expected to facilitate cancer-related research in this domain.

Indexed as

Databases, GeneticDatabases, Nucleic AcidNeoplasmsRNA, Small UntranslatedGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansRNA, Small Untranslated

Identifiers

PMID41062454
PMCPMC12808540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.