Evidence map›Paper›PMID 41062316›Full record

ArticleInternal medicine (Tokyo, Japan)2026

IKZF1 and KRAS Mutated B-cell Acute Lymphoblastic Leukemia with Pseudo-Chédiak-Higashi Granules.

Taichi Murao, Tohru Inaba, Yusuke Yamane, Miki Kiyota, Katsuya Wada, Yasuhito Nannya, Eri Kawata

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Taichi MuraoDepartment of Hematology, Panasonic Health Insurance Organization Matsushita Memorial Hospital, Japan.
Tohru InabaDepartment of Infection Control & Laboratory Medicine, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Yusuke YamaneDepartment of Hematology, Panasonic Health Insurance Organization Matsushita Memorial Hospital, Japan.
Miki KiyotaDepartment of Hematology, Panasonic Health Insurance Organization Matsushita Memorial Hospital, Japan.
Katsuya WadaDepartment of Hematology, Panasonic Health Insurance Organization Matsushita Memorial Hospital, Japan.
Yasuhito NannyaDivision of Hematopoietic Disease Control, Institute of Medical Science, The University of Tokyo, Japan.
Eri KawataDepartment of Hematology, Japanese Red Cross Society, Japanese Red Cross Kyoto Daini Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of a 78-year-old patient with B-cell acute lymphoblastic leukemia (B-ALL), characterized by the presence of pseudo-Chédiak-Higashi (PCH) granules in lymphoblasts. A morphological analysis using transmission electron microscopy revealed heterogeneous blasts with irregular and bilobed nuclei containing PCH granules, identified as autophagosomes. A genomic analysis revealed mutations in IKZF1 and KRAS. The patient's condition was refractory to induction chemotherapy. The morphological heterogeneity of B-ALL with PCH granules poses a diagnostic challenge. Few reports have so far described cases of B-ALL with PCH granules refractory to induction therapy, thus highlighting the need for further investigation to better understand its clinical and pathological features.

Indexed as

Chediak-Higashi SyndromeCytoplasmic GranulesIkaros Transcription FactorMutationPrecursor B-Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins p21(ras)AgedHumansMaleIkaros Transcription FactorIKZF1 protein, humanKRAS protein, humanProto-Oncogene Proteins p21(ras)B-lymphoblastic leukemiapseudo-Chédiak-Higashi granulestransmission electron microscopy

Identifiers

PMID41062316
PMCPMC13222710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.