ArticleJournal of agricultural and food chemistry2025
Protective Effect of Neochlorogenic Acid on Diabetic Nephropathy via Inflammation and Pyroptosis Suppression.
Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Component Analysis Based on UHPLC-Q-Exactive-Orbitrap/MS and Immune Regulatory Activity Assessment by an LPS-Stimulated Macrophages Model of Sacha Inchi Shell (Plukenetia volubilis Linneo) Extract.Chemistry & biodiversity · 2026Article
- Targeting Ferroptosis, Pyroptosis, and NRF2 Signaling with Dietary Polyphenols in Diabetic Microvascular Complications: An Integrative Review.Nutrients · 2026Review
- Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review).International journal of molecular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy (DN) is one of the leading causes of end-stage renal disease. Neochlorogenic acid (nCGA), a polyphenolic compound present in various plant-based foods, has been recognized for its potent antioxidant and anti-inflammatory properties. However, its mechanistic effects on pyroptosis and microRNA signaling in the context of DN remain unclear. We investigated the molecular effects of nCGA on oxidative stress, inflammation, pyroptosis, and miRNA regulation in MES-13 mouse mesangial cells. nCGA enhanced Nrf2 activation, upregulated antioxidant genes, and suppressed ROS accumulation. It inhibited NF-κB signaling and reduced inflammatory proteins and also attenuated pyroptosis by downregulating NLRP3, GSDMD, caspase-1, and IL-1β. MicroRNA profiling revealed dual regulation: nCGA upregulated miR-30a, suppressing NF-κB/TNF-α pathways, and downregulated miR-709, thereby restoring the Nrf2-mediated antioxidant defense. Transfection with miR-30a mimics or miR-709 inhibitors reproduced these protective effects. These findings highlight the dual miRNA-mediated regulation, providing novel therapeutic insights into mitigating oxidative stress and inflammation in diabetic nephropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.