ArticleThe Journal of organic chemistry2025
From Monomers to Nanocapsules: The Role of Structural Features in Amino-Acid-Derived BTA Self-Assembly.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The morphology of supramolecular assemblies can be profoundly influenced by even subtle changes in the molecular structure. In this study, we investigate how variations in amino acid-functionalized benzene-1,3,5-tricarboxamide (BTA) derivatives affect their self-assembly behavior in nonpolar solvents. Specifically, we examine the roles of linker flexibility, steric hindrance introduced by bulky substituents at the 2,4,6-positions, and the nature of the central core (aromatic vs aliphatic). Our results show that these structural changes lead to strikingly different aggregation outcomes, ranging from monomeric species and ill-defined oligomers to well-defined nanocapsules. These findings highlight the importance of precise molecular design in controlling supramolecular self-assembly and demonstrate how specific structural factors dictate the morphology and properties of the resulting materials.
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