Evidence map›Paper›PMID 41061943›Full record

ArticleJournal of pain and symptom management2026

Assessment of a Zero-Shot Large Language Model in Measuring Documented Goals-of-Care Discussions.

Robert Y Lee, Kevin S Li, James Sibley, Trevor Cohen, William B Lober, Danae G Dotolo, Erin K Kross

Abstract read
In one paragraph

Article in Journal of pain and symptom management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Robert Y LeeDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Cambia Palliative Care Center of Excellence at UW Medicine (R.Y.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA. Electronic address: rlee06@uw.edu.
Kevin S LiDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Division of Biomedical and Health Informatics (K.S.L., T.C., W.B.L.), Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA.
James SibleyDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Department of Biobehavioral Nursing and Health Informatics (J.S., W.B.L.), University of Washington, Seattle, Washington, USA.
Trevor CohenDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Division of Biomedical and Health Informatics (K.S.L., T.C., W.B.L.), Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA.
William B LoberDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Division of Biomedical and Health Informatics (K.S.L., T.C., W.B.L.), Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA; Department of Biobehavioral Nursing and Health Informatics (J.S., W.B.L.), University of Washington, Seattle, Washington, USA; Department of Global Health (W.B.L.), University of Washington, Seattle, Washington, USA.
Danae G DotoloDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Cambia Palliative Care Center of Excellence at UW Medicine (R.Y.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA.
Erin K KrossDivision of Pulmonary, Critical Care, and Sleep Medicine (R.Y.L., K.S.L., J.S., T.C., W.B.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA; Cambia Palliative Care Center of Excellence at UW Medicine (R.Y.L., D.G.D., E.K.K.), University of Washington, Seattle, Washington, USA.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Using the Electronic Health Record to Identify and Promote Goals-of-Care Communication for Older Patients with Serious IllnessR01AG062441 · NIA · UNIVERSITY OF WASHINGTON · PI KROSS, ERIN KATHRYN · 2019 to 2023
$3.9M
Palliative Care Research Training GrantT32HL125195 · NHLBI · UNIVERSITY OF WASHINGTON · PI KROSS, ERIN KATHRYN, SHARMA, RASHMI K. · 2015 to 2024
$3.2M
University of Washington Implementation Science Training Program (UW-ISTP)K12K12HL137940 · NHLBI · UNIVERSITY OF WASHINGTON · PI AU, DAVID H, CURTIS, J RANDALL · 2017 to 2021
$2.9M
Improving goals-of-care discussions for patients with chronic life-limiting illness and acute respiratory failureK23HL161503 · NHLBI · UNIVERSITY OF WASHINGTON · PI Robert Ying-Fu Lee · 2022 to 2026
$940k
NCATS NIH HHS UL1 TR002319NHLBI NIH HHS K12 HL137940NHLBI NIH HHS K23 HL161503NHLBI NIH HHS T32 HL125195NIA NIH HHS R01 AG062441
6 · The paper itself

Abstract

contextGoals-of-care (GOC) discussions and their documentation are important process measures in palliative care. However, existing natural language processing (NLP) models for identifying such documentation require costly task-specific training data. Large language models (LLMs) hold promise for measuring such constructs with fewer or no task-specific training data.

objectiveTo evaluate the performance of a publicly available LLM with no task-specific training data (zero-shot prompting) for identifying documented GOC discussions.

methodsWe compared performance of two NLP models in identifying documented GOC discussions: Llama 3.3 using zero-shot prompting; and, a task-specific BERT (Bidirectional Encoder Representations from Transformers)-based model trained on 4,642 manually annotated notes. We tested both models on records from a series of clinical trials enrolling adult patients with chronic life-limiting illness hospitalized over 2018-2023. We evaluated the area under the receiver operating characteristic curve (AUC), area under the precision-recall curve (AUPRC), and maximal F

resultsIn our text corpora, GOC documentation represented <1% of text and was found in 7.3-9.9% of notes for 23-37% of patients. In a 617-patient held-out test set, Llama 3.3 (zero-shot) and BERT (task-specific, trained) exhibited comparable performance in identifying GOC documentation (Llama 3.3: AUC 0.979, AUPRC 0.873, and F

conclusionA zero-shot large language model with no task-specific training performed similarly to a task-specific trained BERT model in identifying documented goals-of-care discussions. This demonstrates the promise of LLMs in measuring novel clinical research outcomes.

Indexed as

Natural Language ProcessingPalliative CarePatient Care PlanningDocumentationElectronic Health RecordsHumansLarge Language ModelsMaleartificial intelligenceelectronic health recordsgoals of carelarge language modelsNatural language processing

Identifiers

PMID41061943
PMCPMC12684854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.