Observational studyRespiratory medicine2025
Metformin use is associated with reduced systemic steroid courses among pediatric asthma patients with diabetes or elevated blood glucose levels.
Observational study in Respiratory medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Metabolic dysfunction, antidiabetic drugs, and asthma: bibliometric evidence, emerging trends, and translational frontiers from 2006 to 2025.Frontiers in endocrinology · 2026Pooled it
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundPatients with asthma and abnormal glucose metabolism have increased asthma exacerbations, worse lung function, and higher health care utilization. Metformin, an insulin-sensitizing agent with anti-inflammatory properties, may modify these outcomes.
objectiveThis study explored the association between metformin use and acute asthma exacerbations in children with asthma with elevated blood glucose or a type 2 diabetes diagnosis.
methodsThis observational study was conducted among children aged 10-17 years with asthma and evidence of type 2 diabetes, abnormal glucose, or serum glucose ≥200 mg/dL, using the Linked Network in TrinetX data. Two cohorts were constructed: a metformin treatment group and a comparison group without metformin. Groups were matched 1:1 using a propensity score algorithm on baseline characteristics. Negative binomial models were used to compare asthma-related healthcare utilizations and systemic steroid courses. Kaplan-Meier analysis using the log-rank test compared the time to-first asthma exacerbation.
resultsAfter propensity score matching, there were 536 children each in the metformin user and comparison groups. Metformin use was associated with a significantly lower rate of systemic corticosteroid courses, with a 42 % reduction compared to the comparison group (IRR = 0.58; 95 % CI: 0.40-0.85; p = 0.005). There was no difference in the median time to the first occurrence of asthma hospitalizations, ER visits, or systemic steroid courses between the metformin use and comparison group.
conclusionMetformin use was associated with a significantly lower rate of systemic corticosteroid courses, although no differences were observed in acute care utilization and in time to first asthma exacerbation.
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