ArticleACS nano2025
A Myeloid Cell-Targeted Immunostimulant Cocktail (MyTai) Enhances Cancer Immunotherapy.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A ribonucleotide carbohydrate system (iRNC) enhances antigen presentation and controls glioblastoma.Theranostics · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The efficacy of tumor vaccines depends in large part on additional immunostimulation of antigen-presenting cells (APC) in tumor microenvironments. Various Toll-like receptors (TLR), and in particular TLR3 stimulation by dsRNA, generate a cellular immune response well suited for vaccines. A major drawback of currently used Poly I:C-based TLR3 agonists is their size heterogeneity, variable stability, as well as the toxicity of lipid nanoparticle (LNP) delivery vehicles. To improve existing platforms, here, we designed a myeloid cell targeting nanoparticle system with a refined TLR3 agonist (NexaVant, NVT) and additionally containing small molecule NF-κB stimulators. We termed this myeloid targeting immune enhancer cocktail "MyTai". MyTai, based on ferrocenoyl-aminoguanidine modified cross-linked bis succinyl cyclodextrin, efficiently charge-complexed NVT and small molecules, resulting in a ∼100 nm diameter nanoparticle. MyTai was shown to be extraordinarily robust, highly efficacious in eradicating multiple tumor types, stable, and characterized by low toxicity when administered systemically. MyTai represents a viable alternative to otherwise toxic LNP RNA delivery platforms for immune stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.