Evidence map›Paper›PMID 41061688›Full record

ArticleCanadian Urological Association journal = Journal de l'Association des urologues du Canada2026

Estimated blood loss to urine output ratio during partial nephrectomy as a predictor of postoperative acute kidney injury in a hereditary renal cancer-enriched population.

Lauren Loebach, Ruben Blachman-Braun, Milan H Patel, Braden Millan, Maria Antony, Julie Solomon, Jaskirat Saini, Sandeep Gurram, W Marston Linehan, Mark W Ball

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Article in Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lauren LoebachUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Ruben Blachman-BraunUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Milan H PatelUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Braden MillanUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Maria AntonyUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Julie SolomonUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Jaskirat SainiUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Sandeep GurramUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
W Marston LinehanUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Mark W BallUrologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe aimed to assess whether the intraoperative estimated blood loss (EBL) to urine output (UOP) ratio is a predictor of postoperative acute kidney injury (AKI) in a cohort of patients enriched with hereditary renal cancer syndromes undergoing partial nephrectomy (PN).

methodsWe performed a retrospective chart review of patients who underwent PN at our institution from January 2006 to October 2024. We recorded and analyzed the clinical, demographic, and intraoperative characteristics of all patients.

resultsA total of 1166 PNs (761 patients and 5903 renal tumors) were analyzed, of which 484 (41.5%) developed postoperative AKI. The average EBL/UOP was 1.06 (0.46-2.35) for patients without AKI and increased as AKI worsened, with a ratio of 5.00 (2.34-9.43) in patients with KDIGO AKI grade 3 (p<0.001). EBL/UOP was associated with AKI in all patients (odds ratio [OR] 1.079, p=0.002) and those with bilateral native kidneys (OR 1.083, p=0.003). After adjustment in patients with a solitary kidney, no AKI association with EBL/UOP (OR 1.039, p=0.447) was found.

conclusionsEBL/UOP is a novel tool associated with the increased risk of developing post-PN AKI in select patients. In multiplex and repeat PNs, a higher ratio can assist the surgical team in identifying patients at risk of developing AKI. Prospective evaluation involving management strategies based on the EBL/UOP is needed to determine its true utility in clinical practice and generalization in the broader PN population.

Identifiers

PMID41061688
PMCPMC13680038

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