Evidence map›Paper›PMID 41061678›Full record

ArticleAging cell2025

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans.

Vincent Marcangeli, Marina Cefis, Rami Hammad, Jordan Granet, Jean-Philippe Leduc-Gaudet, Pierrette Gaudreau, Mylène Aubertin-Leheudre, Marc Bélanger, Richard Robitaille, José A Morais and 1 more

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vincent MarcangeliDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.
Marina CefisDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.
Rami HammadDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.
Jordan GranetDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.
Jean-Philippe Leduc-GaudetGroupe de Recherche en Activité Physique Adaptée, Montréal, Québec, Canada.
Pierrette GaudreauCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Département de médecine, Université de Montréal, Montreal, Quebec, Canada.
Mylène Aubertin-LeheudreDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.
Marc BélangerDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.
Richard RobitailleGroupe de Recherche en Activité Physique Adaptée, Montréal, Québec, Canada.
José A MoraisResearch Institute of the McGill University Health Centre and McGill University, Montreal, Quebec, Canada.
Gilles GouspillouDépartement Des Sciences de L'activité Physique, UQAM, Montreal, Quebec, Canada.

Funding

CIHR 417022Fonds de Recherche du Québec - Santé FRQS-297877Natural Sciences and Engineering Research Council of Canada RGPIN-2021-03724
6 · The paper itself

Abstract

Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged 20-93. No association between circulating taurine levels and age, muscle mass, strength, physical performance, or mitochondrial function was observed, thereby challenging the implication of taurine deficiency as a primary driver of aging in humans.

Indexed as

AgingTaurineAdultAgedAged, 80 and overHumansMaleMiddle AgedYoung AdultTaurineaging biomarkerfunctional capacitiesgerosciencemitochondriamitochondrial functionphysical activitysarcopeniaskeletal muscletaurine

Identifiers

PMID41061678
PMCPMC12507425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.