ArticleJournal of the American Chemical Society2025
Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A novel programmed-cell-death-related prognostic risk model for cervical cancer based on mitochondrial genes.Translational cancer research · 2026Article
- Development of Granzyme A Turn-ON Fluorescent Activity-Based Probes.Chembiochem : a European journal of chemical biology · 2025Article
- Chemical probes for enzyme imaging: challenges in design, synthesis and biomedical applications.Chemical science · 2025Review
Corrections and comments
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Molecular imaging of immune activation holds tremendous potential for the development of novel immunotherapies. In particular, chemical probes capable of detecting immune responses before changes in tumor size occur can guide early therapeutic strategies. Here, we present a quenched activity-based probe targeting granzyme B as a biomarker of antitumor immunity. Through optimization of the peptide recognition element and functional chemical warhead, we have developed an optical imaging probe, Cy5-IEPCya
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Registered trials
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