ArticleJournal of the mechanical behavior of biomedical materials2026
Anisotropic wear behavior of meniscus: Influence of cross-shear and loading magnitude.
Article in Journal of the mechanical behavior of biomedical materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The repetitive wear-and-tear of knee menisci contributes to chronic knee pain and disability, yet the mechanical factors driving this degenerative process are poorly understood. Here we characterize the effect of motion type and loading magnitude on the anisotropic wear behavior of bovine meniscus. Custom pin-on-plate systems applied 60,000 cycles of unidirectional motion or multidirectional (cross-shear) motion by translating a sectioned "plate" of meniscus under a fixed cartilage "pin" that was loaded to generate physiological stress conditions (0.5, 1.0, 1.5 MPa). Pin motion was applied either longitudinal or transverse to the circumferential fibers of the meniscal tissue. We measured the effect of wear testing on meniscal volume loss, compressive mechanical properties, fiber fraying, and superficial layer thickness. A three-fold increase in loading magnitude resulted in a 36% increase in volume loss and a significant increase in fiber fraying. Multidirectional motion resulted in 31% greater volume loss than unidirectional motion, however, this change was not significant. Transverse specimens exhibited 1.8x greater volume loss than longitudinal specimens. Multiple regression revealed that meniscal tissue was more resistant to wear when it had higher initial tissue stiffness and greater initial stress relaxation. For the first time, this study has demonstrated that the meniscus exhibits anisotropic wear behavior that is governed by the compressive loading magnitude. This study provides foundational data and mechanistic insights on the wear behavior of the knee meniscus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.