Evidence map›Paper›PMID 41061379›Full record

ArticlePsychoneuroendocrinology2025

A lifespan approach to biological aging: Early adversity, past-year trauma, and telomere length in women.

Leah Cha, Gabrielle R Rinne, Judith E Carroll, Madeleine U Shalowitz, Sharon Landesman Ramey, Christine Dunkel Schetter, Jennifer A Sumner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Leah ChaDepartment of Psychology, University of California, Los Angeles, USA.
Gabrielle R RinneDepartment of Psychology, University of California, Los Angeles, USA; Department of Psychology, University of Southern California, USA. Electronic address: gabrielle.rinne@ucla.edu.
Judith E CarrollCousins Center for Psychoneuroimmunology, Department of Psychiatry & Biobehavioral Science, David Geffen School of Medicine, Jane & Terry Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, USA.
Madeleine U ShalowitzDepartment of Pediatrics, NorthShore University HealthSystem, USA; Department of Psychiatry, Rush University, USA.
Sharon Landesman RameyFralin Biomedical Research Institute, Departments of Psychology, Neuroscience, and Human Development, Department of Psychiatry & Behavioral Medicine and Pediatrics, Virginia Tech, USA.
Christine Dunkel SchetterDepartment of Psychology, University of California, Los Angeles, USA.
Jennifer A SumnerDepartment of Psychology, University of California, Los Angeles, USA.

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
Community Child Health Network-Lake County, ILU01HD044226 · NICHD · NORTHSHORE UNIV HEALTHSYSTEM RES INST · PI SHALOWITZ, MADELEINE ULLMAN · 2003 to 2011
$3.9M
Community Response to Maternal/Child Health DisparitiesU01HD044245 · NICHD · CEDARS-SINAI MEDICAL CENTER · PI HOBEL, CALVIN J. · 2003 to 2011
$3.4M
Community Child Health Network: District of ColumbiaU01HD044253 · NICHD · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAMEY, SHARON LANDESMAN · 2007 to 2011
$3.3M
Community Child Health Network: BaltimoreU01HD044207 · NICHD · ST. MICHAEL'S HOSPITAL · PI VANCE, MAXINE · 2003 to 2012
$3.2M
Community Maternal &Child Health-Eastern North CarolinaU01HD044219 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THORP, JOHN M · 2003 to 2011
$3.1M
Preconception and Prenatal Stress: Pathways to Child Biology and BehaviorR01HD072021 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUNKEL SCHETTER, CHRISTINE · 2013 to 2017
$3.0M
Data Coordination and Analyses Center for the Community and Child Health NetworkU01HD054791 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHINCHILLI, VERNON M · 2006 to 2011
$2.7M
Community Child Health Research in Washington, D.C.U01NR008929 · NINR · GEORGETOWN UNIVERSITY · PI RAMEY, SHARON LANDESMAN · 2003 to 2006
$630k
Documenting the CAPPR Process in the L.A. Site of the Community Child Health NetwR03HD059584 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WRIGHT, KYNNA N · 2008 to 2009
$138k
NICHD NIH HHS R01 HD072021NICHD NIH HHS R03 HD059584NICHD NIH HHS U01 HD044207NICHD NIH HHS U01 HD044219NICHD NIH HHS U01 HD044226NICHD NIH HHS U01 HD044245NICHD NIH HHS U01 HD044253NICHD NIH HHS U01 HD054791NIMH NIH HHS T32 MH015750NINR NIH HHS U01 NR008929
6 · The paper itself

Abstract

Adverse experiences over the lifespan can increase risk for poor health outcomes, likely operating in part through accelerated biological aging. From a life course perspective, the extent to which adverse experiences in adulthood predict biological aging will vary as a function of early life adversity, yet few studies have tested this. In this cross-sectional, pre-registered study, we examined associations of early life adversity and past-year potentially traumatic events and their interaction with telomere length in a sample of racially and ethnically diverse and predominantly low-income women (n = 127). We also tested hair cortisol as a potential pathway linking early life adversity and potentially traumatic events with telomere length. Women reported on experiences of early life adversity and the number and negative impact of past-year potentially traumatic events during interviews. Buccal cells and hair samples were collected to assess telomere length and cortisol, respectively. More negative impact of past-year potentially traumatic events was associated with shorter telomere length. However, the strength of this association was conditional on early life adversity and strongest at lower levels of early life adversity. Both greater early life adversity and more negative impact of potentially traumatic events were associated with higher hair cortisol, but hair cortisol was not associated with telomere length. Results suggest that early life adversity modifies the association between subsequent trauma and telomere length and advances understanding of how lifespan adversity shapes biological aging. These findings may inform future research to examine dynamic biological processes linking lifespan adverse experiences to health using longitudinal designs.

Indexed as

Adverse Childhood ExperiencesAgingAdultCross-Sectional StudiesFemaleHairHumansHydrocortisoneLife Change EventsMiddle AgedStress, PsychologicalTelomereTelomere HomeostasisTelomere ShorteningHydrocortisoneBiological agingEarly life adversityHair cortisolTelomere lengthTrauma

Identifiers

PMID41061379
PMCPMC12591509

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.