ArticleBlood advances2026
Effect of obexelimab on the production of anti-RBC antibodies and cytokines in patients with warm autoimmune hemolytic anemia.
Article in Blood advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractObexelimab is a bifunctional, nondepleting, humanized monoclonal antibody that binds CD19 and FcγRIIb to inhibit the activity of B-lineage cells. It is currently being evaluated in humans with various autoimmune diseases, including warm autoimmune hemolytic anemia (wAIHA). In this study, we evaluated the in vitro effect of obexelimab on the production of anti-red blood cell (anti-RBC) autoantibodies and cytokines in blood samples collected from a cohort of patients with wAIHA followed at a single tertiary hematological center. Obexelimab reduced the production of anti-RBC autoantibodies by 25% in unstimulated cultures and by 5% to 10% in phytohemagglutinin (PHA)-stimulated cultures, both at 15 and 405 μg/mL. In pokeweed (PWM)-stimulated cultures, obexelimab reached an inhibition of 35% at 405 μg/mL. Obexelimab (15 μg/mL) reduced interleukin-10 (IL-10) production in PHA-stimulated cultures from patients with wAIHA. Moreover, it induced an increase in interferon gamma, IL-2, and IL-17 production (∼20%-30%) and a milder increase in tumor necrosis factor α, IL-10, and transforming growth factor β (∼10%), in PWM-stimulated cultures. Soluble receptor IL-2Ra was slightly reduced and apoptosis antigen 1/FAS was minimally increased in PWM-stimulated blood cell cultures treated with obexelimab (15 μg/mL). Collectively, these findings support the notion that obexelimab exerts an immunomodulatory effect on RBC-specific autoantibody and cytokine production in wAIHA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.