Evidence map›Paper›PMID 41061173›Full record

ReviewAnnual review of medicine2026

Xenotransplantation: Promises and Perils.

Joseph M Ladowski, Nagham Bazzi, Allan D Kirk

Abstract readReview
In one paragraph

Review in Annual review of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Can european law keep pace with biomedical innovation? The reinvention of transplantation regulation.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph M LadowskiDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA; email: joseph.ladowski@duke.edu, allan.kirk@duke.edu.
Nagham BazziDuke Transplant Center, Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Allan D KirkDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA; email: joseph.ladowski@duke.edu, allan.kirk@duke.edu.

Funding

Neonatal Porcine Islet Xenografts for the Treatment of Type 1 DiabetesU01AI090956 · NIAID · EMORY UNIVERSITY · PI KIRK, ALLAN D., LUO, XUNRONG · 2010 to 2024
$14.8M
NIAID NIH HHS U01 AI090956
6 · The paper itself

Abstract

Xenotransplantation of genetically modified pig organs has the potential to change the landscape of transplantation and chronic disease management by providing limitless personalized organs on demand. Decades of progress have resulted in recent US Food and Drug Administration approval for human clinical trials. Understandably, hope for the field is at a maximum, fueled by exciting anecdotal experiences, each providing new insights and questions. While further work is needed before widespread clinical application is plausible, the promise of xenotransplantation has never been more evident. In this review, we seek to highlight recent progress, suggest remaining research questions, and touch on the future of the field.

Indexed as

Transplantation, HeterologousAnimalsAnimals, Genetically ModifiedGraft RejectionHumansSwineend-stage renal diseasegenetically engineered pigpartial heart transplantationtransplantationtriple-knockoutxenocompatibilityxenotransplantation

Identifiers

PMID41061173
PMCPMC13651906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.