ArticleScience advances2025
High-speed photoacoustic and ultrasonic computed tomography of the breast tumor for early diagnosis with enhanced accuracy.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Photoacoustic and ultrasound Imaging of placental functions in gestational diabetes: From diagnosis to precision interventions.Photoacoustics · 2026Review
- Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.Nature biomedical engineering · 2026Review
- Real-time deep learning-based vascular recognition in clinical breast photoacoustic imaging.Photoacoustics · 2026Article
- Photoacoustic-ultrasound endoscopy for assessment of rectal cancer treatment response: A prospective study with T2-weighted MRI radiomics comparison.Photoacoustics · 2026Article
- Hybrid three-dimensional full-view multi-wavelength photoacoustic and ultrasound breast tomography.Photoacoustics · 2026Article
- Maximum fluence for accurate functional photoacoustic microscopy.Photoacoustics · 2026Article
- An ingestible light source for deep photoacoustic imaging.Photoacoustics · 2026Article
- Three-dimensional aperture-driven photoacoustic tomography (3D-ADPAT).Science advances · 2026Article
- Characterization of vascular patterns in endometrial cancer via optical resolution photoacoustic microscopy.Journal of biomedical optics · 2026Article
- Impact of skin pigmentation on photoacoustic tomography: a phantom study.Biophotonics discovery · 2026Article
- Utilizing post-imaging surveys to guide development of photoacoustic computed technology for breast imaging.American journal of surgery · 2026Article
- Vascular Phenotyping with Photoacoustic and Ultrasound Imaging in Cardiovascular Disease: Recent Innovations.Current treatment options in cardiovascular medicine · 2026Review
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed a high-speed dual-modal imaging system (HDMI), designed to concurrently reveal anatomical and hematogenous details of the human breast within seconds. Through innovative system design and technical advancements, HDMI integrates large-view photoacoustic and ultrasonic computed tomography with standardized scanning and batch data processing for computer-aided diagnosis. It achieves dual-modal imaging at a 10-hertz frame rate and completes a whole-breast scan in 12 seconds, providing penetration up to 5 centimeters in vivo. In a clinical study involving 170 patients with 186 breast tumors, we developed a diagnostic model leveraging combined photoacoustic and ultrasound features. In a triple-blinded comparison using pathological diagnosis as the ground truth, HDMI significantly improved diagnostic specificity from 22.5 to 75.0% compared to clinical ultrasonography. This technology shows strong potential for early breast tumor diagnosis, offering enhanced accuracy without the need for ionizing radiation, exogenous contrast agents, pain, invasiveness, operator dependence, or extended examination times.
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