Evidence map›Paper›PMID 41061058›Full record

ArticleScience advances2025

Generating theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization.

Shixiong Chen, Beibei Sun, Lingling Lin, Xinxin Zhao, Yan Zhou, Feng Wu, Huilin Zhao, Jinyao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shixiong ChenShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0009-0004-1984-1253
Beibei SunDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0002-2163-4163
Lingling LinDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0003-4598-5280
Xinxin ZhaoDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0003-3808-5997
Yan ZhouDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0001-9402-1109
Feng WuShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0003-4714-7707
Huilin ZhaoDepartment of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0002-8490-4757
Jinyao LiuShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.ORCID 0000-0002-6044-2033

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral bacteriotherapy is increasingly exploited but faces challenges in simultaneously monitoring treatment process and achieving desirable efficacy. Here, we develop theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization. Using two-step metal ion adsorption and nucleation, bacterial surface is successively mineralized with an inner manganese dioxide/ferric oxide nanoparticle layer and an outer calcium carbonate layer. Upon ingestion, the outer layer neutralizes gastric acid through double-decomposition reaction, protecting bacterial viability and the inner layer. During intestinal passage, the inner layer enables T1/T2 dual-mode magnetic resonance imaging for real-time tracking, whereas the lesion-triggered release of manganese ions allows T1 single-mode pathological detection. The inner layer also exhibits superoxide dismutase and catalase activities, synergizing therapeutic effects with bacteria. Further supported by satisfactory performances in two murine models of

Indexed as

BacteriaNanoparticlesTheranostic NanomedicineAnimalsCalcium CarbonateColitisDisease Models, AnimalHumansMagnetic Resonance ImagingManganese CompoundsMiceOxidesCalcium CarbonateManganese Compoundsmanganese dioxideOxides

Identifiers

PMID41061058
PMCPMC12506964

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.