Evidence map›Paper›PMID 41061049›Full record

ArticleScience advances2025

Ligand-receptor interactions induce and mediate regulatory functions of BATF3

Hui Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes, Funan He, Shuai Wu, Azad Khosh, Weiwei Luo, Jingwei Wang, Maria J Fernandez and 28 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Altered Erythrocyte Function via TLR9-ox-mtDNA Binding Links Mitochondrial Oxidative Damage to Systemic Inflammation in Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Hui YanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-6990-2526
Rui WangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-5305-3283
Suryavathi ViswanadhapalliDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0002-7381-6962
Christian CervantesDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-4784-3879
Funan HeDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0002-4592-4034
Shuai WuDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0003-1818-0831
Azad KhoshDepartment of Molecular Medicine, Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-3267-4280
Weiwei LuoDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-0000-420X
Jingwei WangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-7408-8362
Maria J FernandezDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-4820-821X
Uday P PratapDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-2973-0210
Mustafa KhanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-5430-7572
Karli HintonDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0003-0372-3178
Sai Eashan VankamamidiDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0001-6422-2778
Dariela PerezDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0009-0004-9046-8084
Carlos E RiveraDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0001-9052-557X
Harshita B GuptaDepartment of Biochemistry and Structural Biology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-1003-2658
Fushun ZhangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-0696-8907
Zhenqing YeDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0009-0008-8336-0410
Yidong ChenDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0001-6806-2185
Xiao-Dong LiDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-4349-6996
Gangadhara R SareddyDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0001-9977-3932
Hong ZanDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-2873-7034
Yue LiDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0009-0005-3007-8647
Exing WangDepartment of Cell Systems and Anatomy.ORCID 0000-0003-4644-1306
Evelien M BunnikDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0003-4003-3053
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0001-7053-5009
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3092-1428
Ross M KedlDepartment of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Denver, CO, USA.ORCID 0000-0002-9065-7895
Zhinan YinThe First Affiliated Hospital, Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University, Guangzhou, Guangdong, China.ORCID 0000-0001-6524-8777
Booki MinDepartment of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-2151-9413
Diako EbrahimiProgram of Host-Pathogen Interactions, Texas Biomedical Research Institute, San Antonio, TX, USA.ORCID 0000-0002-8577-0420
Siyuan ZhengDepartment of Population Health Sciences. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0002-1031-9424
Tyler J CurielDepartment of Microbiology and Immunology, Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.ORCID 0000-0001-6962-9411
Yan XiangDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-7633-1629
Ratna K VadlamudiDepartment of Obstetrics and Gynecology. Joe R. and Teresa Lozano Long School of Medicine, UT San Antonio, San Antonio, TX, USA.ORCID 0000-0003-2849-4076
Paolo CasaliDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-8982-5177
Zhenming XuDepartment of Microbiology, Immunology and Molecular Genetics, Joe R. and Teresa Lozano Long School of Medicine, The University of Texas at San Antonio (UT San Antonio), San Antonio, TX, USA.ORCID 0000-0002-5822-0570

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3M
The role of IL-27/Lag3 axis in regulating Foxp3+ regulatory T cell functionR01AI125247 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Booki Min · 2017 to 2026
$3.4M
Viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3-enzymeR01AI179465 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Diako Ebrahimi · 2024 to 2026
$2.5M
IL-27-producing B cells in the antibody responseR01AI153506 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2021 to 2025
$2.2M
Development of new therapeutic approaches for endometrial cancerR01CA267893 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI VADLAMUDI, RATNA K, VISWANADHAPALLI, SURYAVATHI · 2022 to 2025
$1.7M
B cells as a major source of IL-27 cytokine in antibody responses and anti-viral immunityR21AI135599 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2018 to 2019
$419k
NCATS NIH HHS UM1 TR004538NCI NIH HHS R01 CA267893NIAID NIH HHS R01 AI125247NIAID NIH HHS R01 AI153506NIAID NIH HHS R01 AI179465NIAID NIH HHS R21 AI135599
6 · The paper itself

Abstract

B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27-IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 interaction-mediated self-targeting, these cells promoted B cell PD-L1 expression and immune evasion. Mechanistically,

Indexed as

Basic-Leucine Zipper Transcription FactorsB-LymphocytesRepressor ProteinsAnimalsCD40 AntigensChemokine CXCL10FemaleHumansInterleukinsLigandsMiceProtein BindingReceptors, CXCR3Signal TransductionBasic-Leucine Zipper Transcription FactorsCD40 AntigensChemokine CXCL10Cxcl10 protein, mouseInterleukinsLigandsReceptors, CXCR3Repressor ProteinsSNFT protein, mouse

Identifiers

PMID41061049
PMCPMC12506935

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.