Evidence map›Paper›PMID 41061042›Full record

ArticleScience translational medicine2025

Deletion of murine

Ligia B Schmitd, Hannah Hafner, Ayobami Ward, Elham Asghari Adib, Natalia P Biscola, Rafi Kohen, Mitre Athaiya, Meghan Tuttle, Manav Patel, Rachel E Williamson and 14 more

Abstract read
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Ligia B SchmitdDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-1570-6543
Hannah HafnerDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-4908-4132
Ayobami WardDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0009-0008-6616-7694
Elham Asghari AdibDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Natalia P BiscolaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9345-085X
Rafi KohenDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mitre AthaiyaDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-7526-4663
Meghan TuttleDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0009-0006-6204-3171
Manav PatelDepartment of Biology, Ball State University, Muncie, IN, USA.ORCID 0009-0006-6315-7912
Rachel E WilliamsonDepartment of Biology, Ball State University, Muncie, IN, USA.
Emily DesaiDepartment of Biology, Ball State University, Muncie, IN, USA.
Julianna BennettDepartment of Biology, Ball State University, Muncie, IN, USA.
Grace SaxmanDepartment of Biology, Ball State University, Muncie, IN, USA.ORCID 0009-0003-2046-3520
David WilbornDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jaisha ShumpertDepartment of Biology, Ball State University, Muncie, IN, USA.
Xiao-Feng ZhaoDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-7574-7163
Riki KawaguchiDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0002-2489-4825
Daniel H GeschwindDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0003-2896-3450
Ahmet HokeDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-1215-3373
Peter ShragerDepartment of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.
Catherine A CollinsDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1608-6692
Leif A HavtonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1561-4331
Ashley L KalinskiDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-7611-0810
Roman J GigerDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-2926-3336

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Regenerative and Degenerative Responses to Axonal InjuryR01NS069844 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CADIGAN, KENNETH M, COLLINS, CATHERINE A · 2010 to 2024
$5.0M
Immune Metabolism of Peripheral Nervous Tissue Degeneration and RegenerationR01NS141351 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Roman Jeno Giger · 2025 to 2026
$1.1M
Regulation of Neuroinflammation after Peripheral Nerve InjuryR15NS128837 · NINDS · BALL STATE UNIVERSITY · PI KALINSKI, ASHLEY L, ROOSSIEN, DOUGLAS HOWARD · 2023 to 2023
$447k
The contribution of macrophage subpopulations to axon degeneration, nerve inflammation, and regeneration of the injured sciatic nerveF31NS135919 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAFNER, HANNAH JULE · 2024 to 2025
$82k
NIDCR NIH HHS T32 DE007057NINDS NIH HHS F31 NS135919NINDS NIH HHS R01 NS069844NINDS NIH HHS R01 NS141351NINDS NIH HHS R15 NS128837
6 · The paper itself

Abstract

Upon injury to the mammalian peripheral nervous system (PNS), severed axons undergo rapid SARM1-dependent programmed axon death (Wallerian degeneration), but a potential role for

Indexed as

Armadillo Domain ProteinsCellular MicroenvironmentCytoskeletal ProteinsGene DeletionNerve RegenerationPeripheral Nerve InjuriesAnimalsAxonsGanglia, SpinalMiceMice, Inbred C57BLMice, KnockoutMyelin SheathSchwann CellsSciatic NerveArmadillo Domain ProteinsCytoskeletal ProteinsSARM1 protein, mouse

Identifiers

PMID41061042
PMCPMC13663677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.