Evidence map›Paper›PMID 41060992›Full record

ArticlePloS one2025

Comparison of the effects of spark plasma at two different voltages on aspects influencing skin rejuvenation.

Erfan Ghasemi, Mohammad Ali Nilforoushzadeh, Mohammadreza Khani, Mohammad Amir Amirkhani, Maryam Nouri, Parisa Charipoor, Babak Shokri

Abstract readComparative Study
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erfan GhasemiLaser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran.
Mohammad Ali NilforoushzadehSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadreza KhaniLaser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran.ORCID https://orcid.org/0000-0001-7753-1780
Mohammad Amir AmirkhaniSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Maryam NouriSkin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Parisa CharipoorLaser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran.
Babak ShokriLaser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin is not only the body's largest organ but also one of the most noticeable and hard-working parts. Every day, it shields us from things like bumps, changes in temperature, and harmful substances in the environment. But as we age, this protection starts to weaken. Spending too much time in the sun, being exposed to pollution, and other stressors lead to visible signs of aging, such as dry skin, uneven color, fine lines, and a loss of firmness and elasticity. Recently, spark plasma has shown great potential as a gentle and non-invasive way to help the skin heal itself. In earlier research [16], we studied how applying spark plasma at 3.44 kV affected the skin, and the results were very encouraging. Inspired by those findings, we continued with more research. In this study, we tested two different levels of spark plasma-3.44 kV and 4.88 kV-to see how each affected the skin in different ways. We measured changes in skin color, firmness, density, tightness, moisture, and thickness using both MPA9 biophysical tests and ultrasound imaging. We noticed that both levels led to visible improvements in the skin, but the higher voltage had a stronger effect, especially when it came to increasing collagen and speeding up the healing process. Interestingly, there was a brief increase in redness and melanin right after the treatments, but these effects went away and returned to normal within four weeks. Most importantly, there were no scars, long-term irritation, or harmful side effects during or after the treatments.

Indexed as

Plasma GasesRejuvenationSkinSkin AgingAdultFemaleHumansMaleSkin PigmentationPlasma Gases

Identifiers

PMID41060992
PMCPMC12507225

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.