Observational studyPloS one2025
Long-term outcomes of combination therapy with stereotactic body radiation therapy plus cryoablation using liquid nitrogen for stage I non-small cell lung cancer with tumors ≥2 cm.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesRadiation and ablation therapy are used to treat stage I non-small cell lung cancer. However, the local control and survival rates remain unsatisfactory for tumors ≥2 cm. Therefore, this study explored the effectiveness of combination therapy of stereotactic body radiation plus cryoablation in this patient population.
methodsThis retrospective observational study included patients with stage I non-small cell lung cancer ≥2 cm who underwent stereotactic body radiation therapy followed by cryoablation between 2015 and 2023. All tumors were pathologically diagnosed before treatment. Patients received stereotactic body radiation therapy (40-60 Gy/4-10 fractions, median biological effective dose: 100 Gy), followed by cryoablation using liquid nitrogen within 3 weeks of radiation therapy. Study outcomes included local control and survival rates, as well as adverse events.
resultsSixty-four patients were included in the study. The mean tumor diameter was 2.7 ± 0.5 (range, 2.0-4.0) cm. The median follow-up duration was 74 (range, 3-111) months. Five patients (8%) experienced local recurrence after treatment (range: 8-61 months). The 5-year local control and overall survival rates were 93% and 74%, respectively. No patient experienced treatment-related mortality. The most frequent complication was post-cryoablation pneumothorax (40%), with a median drainage period of 2 days. Five patients (8%) experienced radiation pneumonitis; four patients had grade 2 severity and one had grade 3 severity, but all these patients recovered without sequelae.
conclusionCombination therapy with stereotactic body radiation therapy followed by cryoablation is a feasible and favorable treatment for stage I non-small cell lung cancer with tumors ≥2 cm.
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