Trial reportPloS one2025
Walking with blood flow restriction on lower limb muscles post-ACL reconstruction: A within-subject trial.
Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of Preoperative Asymmetry in Vertical Ground-Reaction Force With Knee Extensor Symmetry 1 Year After Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals recovering from anterior cruciate ligament (ACL) reconstruction often exhibit persistent strength deficits that can impair function and delay return to participation in sport and/or physical activity. Blood flow restriction (BFR) training has emerged as a promising strategy to enhance muscle adaptations using low-load exercises, but its effectiveness when combined with walking training in this population remains unclear.
objectiveTo determine the effectiveness of a walking program combined with BFR on muscle strength and thickness at the ankle and knee in patients with ACL reconstruction.
methodsThis within-subject clinical trial included 40 adults (27.1 ± 7.3 years; 21 females, 19 males) who had undergone ACL reconstruction at least 6 months prior and presented with a ≥ 10% strength deficit in the knee extensor muscles of the operated limb. Participants completed a 12-week progressive walking program, with duration (from 12 to 20 minutes) and speed (from 1.25 to 2.00 m.s-1) being progressively increased over the 12 weeks. BFR at 90% occlusion pressure was applied to the weaker limb (WL), while the contralateral limb served as control (CL). The intervention included one supervised and two home-based walking sessions per week. Post-intervention outcomes involved determining changes from baseline in peak torque (PT) of ankle and knee extensors and flexors, as well as muscle thickness (MT) of the gastrocnemius medialis (GM), tibialis anterior (TA), vastus lateralis (VL), and semitendinosus (ST).
resultsAnkle plantarflexor PT increased in both limbs (WL = 51.6%; CL = 11.7%), while dorsiflexor PT increased slightly in the WL (5%). GM thickness increased in both limbs (WL = 1.1%; CL = 0.5%), with no changes in TA. For the knee extensors and flexors, PT increased in both limbs (WL = 33.1% and 25.7%; CL = 14.9% and 8.9%). No significant MT changes were observed in VL or ST.
conclusionsA progressive walking program with BFR was associated with increases in lower limb strength and modest MT changes in individuals post-ACL reconstruction. These findings suggest that this intervention may represent a safe and potentially efficient adjunct to post-ACL rehabilitation. Trial registration: RBR-5gqgs99. https://ensaiosclinicos.gov.br/rg/RBR-5gqgs99.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.