Evidence map›Paper›PMID 41060889›Full record

ArticleJBRA assisted reproduction2025

Association between anti-Mullerian hormone and antithyroid antibodies detectability and positivity in women assisted at a fertility clinic.

Yuri Ian Lima de Oliveira, Arnaldo Couto, Paulo Gallo de Sá, Lenora Maria Camarate Silveira Martins Leão, Ana Beatriz Winter Tavares

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Article in JBRA assisted reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yuri Ian Lima de OliveiraPostgraduate Program in Clinical and Experimental Physiopathology (Fisclinex), Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Arnaldo CoutoPharmacy Department - Rio de Janeiro State University, Rio de Janeiro, Brazil.
Paulo Gallo de SáFERTGROUP - Vida Assisted Reproduction Center, Rio de Janeiro, Brazil.
Lenora Maria Camarate Silveira Martins LeãoEndocrine Service - Department of Internal Medicine - Faculty of Medical Sciences - Rio de Janeiro State University, Rio de Janeiro, Brazil.
Ana Beatriz Winter TavaresPostgraduate Program in Clinical and Experimental Physiopathology (Fisclinex), Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between antithyroid antibodies detectability and positivity and ovarian reserve. Additionally, we aimed to evaluate the correlation between TSH levels and parameters of ovarian reserve [anti-Mullerian (AMH) levels and antral follicle count (AFC)].

methodsSubjects were women seeking assisted reproductive therapy and oocyte cryopreservation. AMH, AFC and antithyroid antibodies were determined. In a subgroup of patients, antithyroid antibodies were stratified into categories for the association analyses. The reference values were as follows: antithyroid peroxidase antibody (TPOAb): undetectable (<9 IU/mL), low detectable (9-21 IU/mL), high detectable (22-34 IU/mL), and positive (> 34 IU/mL); antithyroglobulin antibody (TgAb): undetectable (< 10 IU/mL), low detectable (10-60 IU/mL), high detectable (61-115 IU/ mL), and positive (>115 IU/mL). AMH levels < 1.1 ng/mL and/or AFC < 7 follicles were considered to indicate low ovarian reserve.

resultsA total of 453 patients were enrolled. 24.4% had at least one positive antithyroid antibody. Low detectable values for TPOAb and TgAb were found in 42.3% and 66.9%, respectively. TPOAb and TgAb levels were not statistically different between women with AMH < or ≥ 1.1 ng/mL; there was also no statistically significant difference between antithyroid antibodies levels and AFC < or ≥ 7 follicles. AMH levels did not show significant association with detectability nor positivity of the antithyroid antibodies. No statistically significant correlation was observed between AMH and TSH nor AFC and TSH.

conclusionsAlthough the detectability of TPOAb has been associated with different outcomes, TPOAb and/or TgAb were not associated with ovarian reserve in our study.

Indexed as

Anti-Mullerian HormoneAutoantibodiesOvarian ReserveAdultFemaleFertility ClinicsHumansReproductive Techniques, AssistedThyrotropinAnti-Mullerian Hormoneanti-thyroid autoantibodiesAutoantibodiesThyrotropinAnti-Mullerian hormoneantithyroglobulinantithyroid antibodiesassisted reproductive techniquefemale infertilityinfertilitythyroid autoimmunity

Identifiers

PMID41060889
PMCPMC12694964

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