ArticleJournal of neurophysiology2025
Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents.
Teresa S Darcey, Justin Shane Hooper, Sanjay S Nair, Karina V Lurye, Seol-Hee Kim, Stephen H Hadley, Mayur J Patil, Thomas E Taylor-Clark
Abstract read
In one paragraphArticle in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Teresa S DarceyMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-7186-977X Justin Shane HooperMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Sanjay S NairMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-1510-1010 Karina V LuryeMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Seol-Hee KimMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Stephen H HadleyMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Mayur J PatilMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.
Thomas E Taylor-ClarkMolecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.ORCID 0000-0002-5056-2699 Funding
The Role of Mitochondrial Metabolism in Neutrophilic Lung InflammationR01HL152210 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NOTO, MICHAEL JAMES · 2020 to 2024
$2.6MRemodeled airway irritant reflexes as a cause of serious cardiovascular eventsR01HL152219 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI TAYLOR-CLARK, THOMAS EDWARD · 2021 to 2024
$2.1MTraining in Research on Vascular Inflammation and InjuryT32HL160529 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Sarah Y Yuan · 2022 to 2026
$1.1MHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL152210HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL160529NHLBI NIH HHS R01 HL152210NHLBI NIH HHS R01 HL152219NHLBI NIH HHS T32 HL160529
6 · The paper itselfAbstract
Activation of airway sensory afferent nerves causes respiratory and autonomic reflexes. Most airway afferents are activated by noxious stimuli, such as inflammation, irritants, and pollutants. Activation evokes protective reflexes such as cough, bronchospasm, and changes in respiration and cardiovascular function. Airway nociceptors, projecting from the vagal ganglia (nodose and jugular ganglion), are heterogeneous with respect to gene expression and neuroanatomy. Here, we have characterized the cardiorespiratory reflexes in conscious mice evoked by activation of specific afferent subsets by inhaled stimuli. Capsaicin (TRPV1 agonist) and allyl isothiocyanate (AITC, TRPA1 agonist) evoked bradypnea associated with increased tidal volume and increased time of inspiration (
Indexed as
Heart RateNeurons, AfferentNociceptorsReflexRespirationVagus NerveAnimalsBradycardiaCapsaicinIsothiocyanatesMaleMiceMice, Inbred C57BLNodose GanglionTRPA1 Cation ChannelTRPV Cation ChannelsCapsaicinIsothiocyanatesTRPA1 Cation ChannelTrpa1 protein, mouseTRPV1 protein, mouseTRPV Cation Channelsbronchopulmonary sensory nervesnociceptive reflexesradiotelemetrywhole body plethysmography
Identifiers
PMID41060811
PMCPMC12571050
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