Evidence map›Paper›PMID 41060706›Full record

Trial reportMolecular pharmaceutics2025

Nonclinical and Clinical Assessments of an Optimized Tablet Formulation of the Novel HER2-Selective Tyrosine Kinase Inhibitor Zongertinib: Focus on Relative Bioavailability and Impact of Variation of Gastric pH.

Stefan Wölke, Behbood Sadrolhefazi, Habib Esmaeili, Sven Wind, Simone M Blattner, Guanfa Gan, Dongmei Qiang, Andrea Schirmer, Fabian Müller

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Molecular pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefan WölkeBoehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach an der Riss, Germany.
Behbood SadrolhefaziBoehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States.ORCID 0009-0004-3321-0642
Habib EsmaeiliStaburo GmbH, Aschauer Straße 26a, 81549 Munich, Germany.
Sven WindBoehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach an der Riss, Germany.
Simone M BlattnerBoehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach an der Riss, Germany.ORCID 0009-0000-6581-8514
Guanfa GanBoehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States.
Dongmei QiangBoehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States.ORCID 0009-0002-4541-4525
Andrea SchirmerBoehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877-0368, United States.ORCID 0009-0006-4286-7683
Fabian MüllerBoehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397 Biberach an der Riss, Germany.ORCID 0000-0002-0483-0293

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zongertinib (BI 1810631), a novel orally administered HER2-specific tyrosine kinase inhibitor, has recently received accelerated approval in the United States and China for patients with advanced, previously treated

Indexed as

Protein Kinase InhibitorsPyridinesAdministration, OralAdultAnilidesAnimalsBiological AvailabilityCross-Over StudiesDogsDrug CompoundingHumansHydrogen-Ion ConcentrationMaleQuinolinesTabletsTyrosine Kinase InhibitorsAnilidesGSK 1363089Protein Kinase InhibitorsPyridinesQuinolinesTabletsTyrosine Kinase InhibitorsbioavailabilityHER2pharmacokineticstyrosine kinase inhibitorzongertinib

Identifiers

PMID41060706
PMCPMC12587387

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.