Observational studyIndian pediatrics2026
Cytomegalovirus Secretion in Breast Milk of Mothers Delivering at ≤ 32 Weeks' Gestation: A Prospective Observational Study.
Observational study in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
Funding
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Abstract
objectivesPreterm neonates are at risk of symptomatic postnatal cytomegalovirus (pCMV) acquired from CMV-positive breast milk intake. This study ascertained the proportion of mothers delivering at ≤ 32 weeks' gestation with CMV lactatia.
methodsThis prospective study included mother-infant dyads delivered at ≤ 32 weeks' gestation. CMV was detected in breast milk by quantitative DNA PCR. For the proportion of neonates who tested positive for CMV DNA (urine or blood) at 4-6 weeks of age, clinical outcomes were also measured. CMV load > 42.5 copies/mL was considered positive. Virologic (breast milk and infant blood/urine CMV PCR) and clinical correlates were evaluated.
resultsOut of the 93 mothers whose fresh breast milk was tested, 50 (53.7%, 95%CI 42.3, 55.9%) were positive for CMV. Out of 43 infants who were tested for CMV in blood or urine at 4-6 weeks of postnatal age, 10 (23%, 95%CI 18.1, 28.6%) turned positive. Significant differences were noted in the duration of respiratory support [47.5 (30, 73) vs 7 (3, 30) days; P = 0.002] and hospital stay [86.5 (80, 98) vs 51 (31, 65) days, P < 0.001] between CMV positive and negative infants. CMV-positive status was not an independent risk factor for bronchopulmonary dysplasia [aOR 5.3 (95%CI 0.9-31.0)] and retinopathy of prematurity requiring therapy [aOR 17.3 (95%CI 0.9-194.2)].
conclusion53.7% of mothers delivering prematurely had CMV lactatia; 23% of their infants were positive for CMV at 4-6 weeks of age.
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