Evidence map›Paper›PMID 41060547›Full record

ArticleDiscover oncology2025

Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis.

Li Wang, Jian-Wei Yang, Kang-Yu Wang, Si-Yu Chen, Li Yang

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Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Li Wang *Department of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University, Lanzhou, China.
Jian-Wei Yang *Department of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University, Lanzhou, China.
Kang-Yu Wang *Department of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University, Lanzhou, China.
Si-Yu ChenDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University, Lanzhou, China. 1432996042@qq.com.
Li YangDepartment of Urology, Gansu Province Clinical Research Center for Urinary System Disease, The Second Hospital of Lanzhou University, Lanzhou, China. ery_yangli@lzu.edu.cn.

Funding

Gansu Province Science and Technology Grant 24YFFA049Gansu Provincial Department of Science and Technology, Natural Science Foundation 25JRRA584
6 · The paper itself

Abstract

backgroundWhile epidemiological studies suggest an association between leukocyte telomere length (LTL) and renal cell carcinoma (RCC), the genetic basis underlying this relationship remains to be elucidated.

methodsWe analyzed genome-wide association studies (GWAS) summary statistics from LTL (n = 472,174) and RCC(3,926 cases; 378,749 controls) cohorts. Comprehensive cross-trait analyses examined genetic correlations, causality, tissue enrichment, and pleiotropic loci.

resultsWe identified significant genetic correlation between LTL and RCC (correlation = 0.0379, p = 0.0012) at both genome-wide and local levels. Meta-analysis revealed 25 novel pleiotropic loci, including a co-localized variant (rs1874330). Novel tissue-specific enrichment was observed in uterine and testicular tissues, with shared functional genes affecting both traits. Mendelian randomization provided evidence for a causal effect of LTL on RCC risk.

conclusionThis study establishes genetic links between LTL and RCC through shared architecture, tissue-specific patterns, and causal pathways, suggesting potential therapeutic targets and risk markers for future validation.

Indexed as

Genetic architectureGenome-wide cross-trait analysisLeukocyte telomere lengthRCC

Identifiers

PMID41060547
PMCPMC12508358

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