ReviewHealth economics review2025
Global economic burden of diabetic related hypoglycemia: a systematic review of cost of illness studies.
Review in Health economics review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, diabetic hypoglycemic events are increasing, and this review aimed to synthesize global evidence on the economic burden of hypoglycemia.
methodWe conducted a systematic search in both databases (PubMed and Scopus) and a forward citation search. We included worldwide studies regardless of publication year. Two independent authors are involved in screening, selection, extraction, and quality appraisal. We used a consensus-based checklist for quality appraisal. We reported the costs in 2024 international dollars. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, and registered the review with the International Prospective Register of Systematic Reviews (CRD420251069256).
resultWe reached out to 1235 articles and included 29 in the final report from high- and middle-income countries. Most studies estimated costs using prevalence-based and health system perspectives. The average direct and indirect costs per event per patient ranged from $1.90 to $24,932.73 and $3.46 to $3,339.34, respectively. The average annual direct cost per patient ranged from $1,938.41 to $25,092.76. This direct expense emerged from medications, consultation services, hospitalization, emergency care, and other services. Indirect costs primarily identified productivity losses due to sick leave, late arrivals, and early departures from work, with annual monetary estimates per patient ranging from $2,504.22 to $16,129.64. Patient direct costs were generally higher than the indirect costs. Annual hypoglycemia attributable costs ranged from $1,431.72 to $14,414.20 per patient per year. The annual national economic burden of hypoglycemia was substantial, ranging from $39.04 to $3.03 billion. Diabetes severity, type of diabetes, treatment regimen, and health facility level are sources of cost variation.
conclusionThis systematic review concludes that diabetes-related hypoglycemia imposes a substantial economic burden, with both direct and indirect costs being significant. Preventive efforts focusing on hypoglycemia and its contributing factors are crucial to mitigate the financial impact on patients, healthcare providers, and the health system.
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