ArticleJournal of endocrinological investigation2026
Characterization of the secretory profile of gonadotroph pituitary tumors.
Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Functioning gonadotroph macroadenoma associated with multiple endocrine neoplasia type 1.JCEM case reports · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGonadotroph pituitary tumors (GnPiT) represent 70-75% of clinically non-functioning tumors in surgical series. Their proportion has increased with the diagnostic use of transcription factors in addition to gonadotropin immunostaining, but the prevalence of functioning cases has not been re-evaluated. The aim is to provide a comprehensive, up-to-date characterization of GnPiT, including pathological subtyping and search for whispering/functioning cases (
methodsA single-center retrospective study of patients who received a pathological diagnosis of GnPiT between 2020 and 2022. Clinical, hormonal, and pathological data were analyzed according to sex and age, with short-term post-operative re-evaluation. Histological subtypes were defined according to hormone immunostaining.
results151 patients (103 M, 48 F) were studied. The diagnosis was incidental in 72 cases (48.0%). Age distribution at diagnosis was normal in males (median 63 years (25-89)), and bimodal in females (median age 58 years (26-84)). A single case of overt hyperfunction, revealed by ovarian hyperstimulation syndrome, occurred. The prevalence of likely
conclusionClinically relevant hypersecretion remains uncommon in GnPiT but may be under-evaluated. No significant differences in tumor behavior emerged among pathological subtypes.
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