Evidence map›Paper›PMID 41060490›Full record

ReviewDermatology and therapy2025

Dermatologic Comorbidities Associated with Atopic Dermatitis Towards a Shared Therapeutical Approach: A Narrative Review.

Maria Esposito, Alessandro Giunta, Andrea De Berardinis, Lina Maria Magnanimi, Maria Concetta Fargnoli, Cataldo Patruno, Luca Potestio, Maddalena Napolitano

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dermatology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Esposito *Dermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio-Coppito 2, 67100, L'Aquila, Italy.ORCID http://orcid.org/0000-0002-4773-6993
Alessandro Giunta *Dermatology Unit, Department of Medical Sciences, Azienda Ospedaliera Policlinico Tor. Vergata, Rome, Italy.
Andrea De BerardinisDermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio-Coppito 2, 67100, L'Aquila, Italy.
Lina Maria MagnanimiDermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio-Coppito 2, 67100, L'Aquila, Italy. linamaria.magnanimi@graduate.univaq.it.
Maria Concetta FargnoliDermatology, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Via Vetoio-Coppito 2, 67100, L'Aquila, Italy.
Cataldo PatrunoDepartment of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.
Luca Potestio *Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Maddalena Napolitano *Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAtopic dermatitis (AD) is a chronic inflammatory skin condition commonly associated with other dermatologic comorbidities, which can complicate management and affect treatment outcomes. This review aims to analyse the dermatologic comorbidities of AD, their underlying mechanisms, and therapeutic implications, with a focus on their management in clinical practice.

methodsA narrative review was conducted by searching PubMed, Embase, Cochrane and ClinicalTrials.gov, using terms related to AD and its comorbidities, including allergic contact dermatitis, alopecia areata, prurigo nodularis, psoriasis, hidradenitis suppurativa and chronic spontaneous urticaria.

resultsThe literature highlights a strong association between AD and several dermatologic comorbidities, including allergic contact dermatitis, alopecia areata, chronic spontaneous urticaria, hidradenitis suppurativa, psoriasis, prurigo nodularis and vitiligo. Promising therapeutic effects were observed with JAK inhibitors, dupilumab and other biologics across multiple comorbid condition.

conclusionRecognizing comorbidities in AD is critical for effective management. Tailored therapies targeting both AD and its comorbidities, based on shared immunological mechanisms, may improve outcomes. Further research is needed to optimize treatment strategies and explore combination therapies for patients with both AD and comorbid dermatological conditions.

Indexed as

Atopic dermatitisBiologic treatmentComorbiditiesSmall molecules

Identifiers

PMID41060490
PMCPMC12619867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.