Evidence map›Paper›PMID 41060446›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Effect of a digital tool on breast cancer specific health-related quality of life and psychological distress: secondary results from the ADAPT study.

Noelle J M C Vrancken Peeters, Sofia Georgopoulou, Rafal Kulakowski, Emma Hainsworth, Emma Lidington, Sophie E McGrath, Jillian Noble, Leyla Azarang, Olga Husson, Susanne Cruickshank

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03866655 (Evaluating a Digital Tool for Supporting Breast Cancer Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03866655 naunknown statusnot on this map

Evaluating a Digital Tool for Supporting Breast Cancer Patients: A Prospective Randomised Controlled Trial

TypeinterventionalSponsorRoyal Marsden NHS Foundation TrustRan2019 to 2022Enrolled165ConditionsBreast CancerArmsOWise
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noelle J M C Vrancken PeetersDepartment of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands.
Sofia GeorgopoulouThe Royal Marsden Hospital, London, UK.
Rafal KulakowskiImperial College Health Partners, London, UK.
Emma HainsworthThe Royal Marsden Hospital, London, UK.
Emma LidingtonThe Royal Marsden Hospital, London, UK.
Sophie E McGrathThe Royal Marsden Hospital, London, UK.
Jillian NobleThe Royal Marsden Hospital, London, UK.
Leyla AzarangDepartment of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands.
Olga HussonDepartment of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, 1066 CX, Amsterdam, The Netherlands. o.husson@nki.nl.
Susanne CruickshankThe Royal Marsden Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis report presents the secondary outcomes of the ADAPT trial, focusing on the impact of a digital tool designed to support people affected by breast cancer, on breast cancer-specific health-related quality of life (HRQoL) and psychological distress over the first year from diagnosis.

methodsWomen with early-stage breast cancer were randomly assigned (1:1) to standard care (control) or standard care plus the breast cancer digital tool (intervention). Data were collected using a demographic questionnaire, the European Organization for Research and Treatment of Cancer Core Quality of Life questionnaire BR45 (EORTC QLQ-BR45) for breast cancer-specific HRQoL, and the Hospital Anxiety and Depression Scale (HADS) for psychological distress at baseline, 6 weeks, 3 months, 6 months, and 1 year from diagnosis. Linear mixed effect model regression was used to assess the effect of the digital tool over time while correcting for intra-participant correlation.

resultsThere were no significant differences (p > 0.05) in the EORTC QLQ-BR45 scales and items and HADS scores between participants in the intervention and control groups when adjusted for the primary tumor stage.

conclusionThe breast cancer digital tool did not have a significant effect on breast cancer-specific HRQoL and psychological distress over time. The results are consistent with the findings of the primary ADAPT paper, which demonstrated that the digital tool did not have a significant effect on patient activation, HRQoL, and health status. There is a need for personalized support and strategies to enhance digital tool adherence, offering more customized self-management approaches for people affected by breast cancer in the future.

trial registrationThe study was registered at https://clinicaltrials.gov (NCT03866655) on 7 March 2019 ( https://clinicaltrials.gov/study/NCT03866655 ). The full protocol is accessible through the following link: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-019-3971-6 .

Indexed as

Breast NeoplasmsPsychological DistressQuality of LifeStress, PsychologicalAdultAgedFemaleHumansMiddle AgedSurveys and QuestionnairesBreast cancerEHealthHealth-related quality of life (HRQoL)Psychological distressSupportive care

Identifiers

PMID41060446
PMCPMC12507968

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.