Trial reportCerebellum (London, England)2025
Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation.
Trial report in Cerebellum (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
The cerebellum undergoes significant age-related changes linked to poor balance in older adults. Although multi-session cerebellar iTBS combined with rehabilitation has been used in some clinical populations, its isolated effects in community-dwelling healthy older adults remain unknown, particularly in context of balance control and underlying cerebellar-motor cortex (M1) interactions. We tested whether a single-session, sham-controlled, cerebellar iTBS-only intervention could modulate balance and cerebellar-motor cortex (M1) interactions in community-dwelling older adults without neurological disease. The effects of cerebellar intermittent theta-burst stimulation (iTBS) on balance control and underlying cerebellar-motor cortex (M1) interactions in this population remain unclear. We investigated whether cerebellar iTBS led to [1] improved standing balance, and [2] changes in cerebellar-M1interactions measured using cerebellar brain inhibition (CBI) in older adults. Forty older adults were randomized to receive Active (n = 20) or Sham (n = 20) iTBS to the right lateral cerebellum. We measured postural sway (95% ellipse area of the center of pressure) during standing and CBI before iTBS and at multiple time points up to 30 min post-stimulation. Compared to sham, a single session of active iTBS reduced postural sway, with balance improvements sustained for at least 30 min post-stimulation. Cerebellar iTBS did not significantly alter CBI. Our results support the neuroplastic potential of the cerebellum as a viable target for therapeutic interventions aimed at improving balance in aging, potentially influencing circuits beyond direct cerebellar-M1 motor pathways.
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